PMID- 16365748
OWN - NLM
STAT- MEDLINE
DCOM- 20070116
LR  - 20181113
IS  - 0031-6970 (Print)
IS  - 0031-6970 (Linking)
VI  - 62
IP  - 1
DP  - 2006 Jan
TI  - The gap between evidence-based medicine and daily practice in the management of 
      paediatric asthma. A pharmacy-based population study from The Netherlands.
PG  - 51-5
AB  - OBJECTIVE: We evaluated the adherence to national guidelines for the treatment of 
      asthma in childhood. METHODS: Prescriptions for anti-asthma medication for 
      children (0-14 years of age) were retrieved from the InterAction DataBase (IABD) 
      for the year 2002. These were compared with recommendations found in national 
      guidelines. RESULTS: Anti-asthma medication was prescribed for 3,612 children 
      (5%) of the paediatric population. Inhaled medication was prescribed for 3,554 
      (98%) children. In 1,940 of 1,993 (97%) of the children under the age of 6 years 
      pressurised metered dose inhalers (pMDIs) were given. Short-acting beta2-agonists 
      had not been prescribed in the previous 2-year period in 559 children (15%), 543 
      children older than 8 years (36%) did not receive a prescription for a dry powder 
      inhalator and 239 children (7%) had more than one type of inhalator. Long-acting 
      beta2-agonists were prescribed in 396 children, but without concomitant inhaled 
      corticosteroids (ICS) in 35 children (9%). CONCLUSIONS: Inhalation therapy as the 
      method of choice in asthma therapy and the use of pMDI in preschool children are 
      widely accepted in the Netherlands. Not all children have been prescribed 
      bronchodilators. Some children have more than one type of inhaler device and 
      others use long-acting beta2-agonists not in combination with ICS. Although 
      national and international guidelines about the treatment of asthma in children 
      offer evidence-based advice, important principles are not followed. Effective 
      interventions aimed at implementing existing guidelines into daily practice are 
      urgently needed.
FAU - de Vries, Tjalling W
AU  - de Vries TW
AD  - Department of Paediatrics, Medical Centre Leeuwarden, P.O. Box 888, 8901 BR, 
      Leeuwarden, The Netherlands. tjalling.de.vries@znb.nl
FAU - Tobi, Hilde
AU  - Tobi H
FAU - Schirm, Eric
AU  - Schirm E
FAU - van den Berg, Paul
AU  - van den Berg P
FAU - Duiverman, Eric J
AU  - Duiverman EJ
FAU - de Jong-van den Berg, Lolkje T W
AU  - de Jong-van den Berg LT
LA  - eng
PT  - Journal Article
DEP - 20051220
PL  - Germany
TA  - Eur J Clin Pharmacol
JT  - European journal of clinical pharmacology
JID - 1256165
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Adrenergic beta-Agonists)
RN  - 0 (Anti-Asthmatic Agents)
SB  - IM
MH  - Adolescent
MH  - Adrenal Cortex Hormones/administration & dosage/therapeutic use
MH  - Adrenergic beta-Agonists/administration & dosage/therapeutic use
MH  - Anti-Asthmatic Agents/administration & dosage/*therapeutic use
MH  - Asthma/*drug therapy
MH  - Child
MH  - Child, Preschool
MH  - Drug Utilization Review
MH  - Evidence-Based Medicine
MH  - Female
MH  - Guideline Adherence/*standards
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Metered Dose Inhalers
MH  - Netherlands/epidemiology
MH  - Practice Guidelines as Topic/*standards
EDAT- 2005/12/21 09:00
MHDA- 2007/01/17 09:00
CRDT- 2005/12/21 09:00
PHST- 2005/10/12 00:00 [received]
PHST- 2005/11/09 00:00 [accepted]
PHST- 2005/12/21 09:00 [pubmed]
PHST- 2007/01/17 09:00 [medline]
PHST- 2005/12/21 09:00 [entrez]
AID - 10.1007/s00228-005-0065-z [doi]
PST - ppublish
SO  - Eur J Clin Pharmacol. 2006 Jan;62(1):51-5. doi: 10.1007/s00228-005-0065-z. Epub 
      2005 Dec 20.