PMID- 1636726
OWN - NLM
STAT- MEDLINE
DCOM- 19920821
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 263
IP  - 1 Pt 1
DP  - 1992 Jul
TI  - IL-6 enhances TNF-alpha- and IL-1-induced increase of Mn superoxide dismutase 
      mRNA and O2 tolerance.
PG  - L22-6
AB  - Tumor necrosis factor-alpha (TNF-alpha), interleukin-1 alpha (IL-1), and 
      interleukin-6 (IL-6) are multifunctional cytokines produced by a number of cells 
      in response to endotoxin. We have previously demonstrated (M.-F. Tsan, J. E. 
      White, T. A. Santana, and C. Y. Lee. J. Appl. Physiol. 68: 1211-1219, 1990, and 
      M.-F. Tsan, C. Y. Lee, and J. E. White. J. Appl. Physiol. 71: 688-697, 1991) that 
      tracheal insufflation of 5 micrograms of TNF-alpha or 1 microgram of IL-1 
      markedly protects rats against O2 toxicity and enhances pulmonary Mn superoxide 
      dismutase (Mn SOD) activity. We now report that TNF-alpha and IL-1 at 
      subprotective doses, e.g., 1 and 0.2 micrograms, respectively, act 
      synergistically in protecting rats against O2 toxicity. Likewise, TNF-alpha and 
      IL-1 at 0.005 microgram/ml each act synergistically in enhancing endothelial cell 
      Mn SOD, but not Cu,Zn SOD mRNA levels. IL-6 at 5 or 10 micrograms provides no 
      protective effect in rats against O2 toxicity and at up to 0.5 microgram/ml has 
      no apparent effect on endothelial cell Mn or Cu,Zn SOD mRNA levels. However, IL-6 
      markedly enhances TNF-alpha- and IL-1-induced increases in Mn SOD mRNA levels and 
      O2 tolerance. These results support an important role of Mn SOD in the protection 
      against O2 toxicity.
FAU - Tsan, M F
AU  - Tsan MF
AD  - Research Service, Samuel S. Stratton Department of Veterans Affairs Medical 
      Center, Albany, New York.
FAU - White, J E
AU  - White JE
FAU - Del Vecchio, P J
AU  - Del Vecchio PJ
FAU - Shaffer, J B
AU  - Shaffer JB
LA  - eng
GR  - HL-39631/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Cytokines/administration & dosage/*pharmacology
MH  - Drug Synergism
MH  - Hypoxia/mortality
MH  - Interleukin-1/pharmacology
MH  - Interleukin-6/pharmacology
MH  - Intubation, Intratracheal
MH  - Male
MH  - Oxygen/*pharmacology
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Superoxide Dismutase/*genetics/metabolism
MH  - Tumor Necrosis Factor-alpha/pharmacology
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
AID - 10.1152/ajplung.1992.263.1.L22 [doi]
PST - ppublish
SO  - Am J Physiol. 1992 Jul;263(1 Pt 1):L22-6. doi: 10.1152/ajplung.1992.263.1.L22.