PMID- 1636797
OWN - NLM
STAT- MEDLINE
DCOM- 19920824
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 263
IP  - 1 Pt 2
DP  - 1992 Jul
TI  - Differential baroreceptor reflex modulation by centrally infused angiotensin 
      peptides.
PG  - R89-94
AB  - The present study was designed to investigate the effect of 
      intracerebroventricular (icv) and intravenous (iv) infusion of angiotensin 
      (ANG)-(1-7), ANG III, and ANG II on the baroreceptor control of heart rate (BHR) 
      in conscious rats. Reflex changes in HR were elicited by bolus iv injection of 
      either phenylephrine or sodium nitroprusside before and within 1 and 3 h of icv 
      infusion of ANG II (n = 10), ANG III (n = 9), ANG-(1-7) (n = 9), or saline (n = 
      9) at a rate of 3 nmol.7.5 microliter-1.h-1. In another group of animals (n = 
      23), iv infusion of the same amount of ANG peptides was carried out at a rate of 
      0.7 ml/h. The average ratio of changes in HR in beats per minute and changes in 
      mean arterial pressure (MAP, mmHg) was used as an index of BHR sensitivity. ANG 
      II and ANG III produced a significant increase in the basal levels of MAP, but 
      only during the first hour of infusion (iv or icv). No significant changes in 
      baseline HR were observed. ANG-(1-7) and saline infusion did not change basal 
      levels of HR or MAP (iv or icv). ANG II (iv and icv) and ANG III (icv) caused a 
      significant decrease in the BHR sensitivity for reflex bradycardia. In contrast, 
      icv infusion of ANG-(1-7) induced a significant increase in BHR sensitivity for 
      reflex bradycardia (-3.0 +/- 0.3, 1 h, and -2.8 +/- 0.1 beats.min-1.mmHg-1, 3 h 
      vs. -2.1 +/- 0.2 beats.min-1.mmHg-1, before infusion).(ABSTRACT TRUNCATED AT 250 
      WORDS)
FAU - Campagnole-Santos, M J
AU  - Campagnole-Santos MJ
AD  - Department of Physiology and Biophysics, Federal University of Minas Gerais, 
      Brazil.
FAU - Heringer, S B
AU  - Heringer SB
FAU - Batista, E N
AU  - Batista EN
FAU - Khosla, M C
AU  - Khosla MC
FAU - Santos, R A
AU  - Santos RA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Peptide Fragments)
RN  - 11128-99-7 (Angiotensin II)
RN  - 12687-51-3 (Angiotensin III)
RN  - 9041-90-1 (Angiotensin I)
RN  - IJ3FUK8MOF (angiotensin I (1-7))
SB  - IM
MH  - Angiotensin I
MH  - Angiotensin II/*pharmacology
MH  - Angiotensin III/*pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Brain/*physiology
MH  - Heart Rate/drug effects/physiology
MH  - Injections, Intraventricular
MH  - Male
MH  - Peptide Fragments/*pharmacology
MH  - Pressoreceptors/*physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reflex/*physiology
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
AID - 10.1152/ajpregu.1992.263.1.R89 [doi]
PST - ppublish
SO  - Am J Physiol. 1992 Jul;263(1 Pt 2):R89-94. doi: 10.1152/ajpregu.1992.263.1.R89.