PMID- 16368522
OWN - NLM
STAT- MEDLINE
DCOM- 20060602
LR  - 20190902
IS  - 1093-9946 (Print)
IS  - 1093-4715 (Linking)
VI  - 11
DP  - 2006 May 1
TI  - Dendritic cells and (CD4+)CD25+ T regulatory cells: crosstalk between two 
      professionals in immunity versus tolerance.
PG  - 1360-70
AB  - Dendritic cells (DCs) are professional antigen presenting cells (APCs). 
      (CD4+)CD25+ T regulatory cells (T regs) are recognized as professional regulatory 
      cells. DCs not only initiate T cell immunity by uptake, processing and 
      presentation of specific antigens, but also induce immune tolerance by deletion 
      of T cells and/or induction of regulatory T cells. (CD4+)CD25+ T regs maintain 
      immune tolerance by suppressing the function of CD4+ and CD8+ T cells, B cells, 
      macrophages, DCs and NK cells. It would be inconceivable that the delicate 
      balance between immunity and tolerance could be kept impeccable without the 
      crosstalk between DCs and (CD4+)CD25+ T regs. This review focuses on the recent 
      development in our understanding of DCs and (CD4+)CD25+ T regs in immune 
      tolerance, with transforming growth factor-beta (TGF-beta) serving as a potential 
      link between these two professionals.
FAU - Chen, Wanjun
AU  - Chen W
AD  - Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute 
      of Dental and Craniofacial Research, National Institutes of Heath, 30, Bethesda, 
      MD 20892, USA. wchen@mail.nih.gov
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
DEP - 20060501
PL  - United States
TA  - Front Biosci
JT  - Frontiers in bioscience : a journal and virtual library
JID - 9709506
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (CTLA-4 Antigen)
RN  - 0 (CTLA4 protein, human)
RN  - 0 (FOXP3 protein, human)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase)
RN  - 0 (Interleukin-6)
RN  - 0 (Receptors, Interleukin-2)
RN  - 0 (Transforming Growth Factor beta)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Antigens, CD
MH  - Antigens, Differentiation/metabolism
MH  - CD4-Positive T-Lymphocytes/*metabolism
MH  - CD8-Positive T-Lymphocytes/metabolism
MH  - CTLA-4 Antigen
MH  - Dendritic Cells/*metabolism
MH  - Forkhead Transcription Factors/metabolism
MH  - Humans
MH  - *Immune System
MH  - *Immune Tolerance
MH  - Indoleamine-Pyrrole 2,3,-Dioxygenase/pharmacology
MH  - Interleukin-10/metabolism
MH  - Interleukin-6/metabolism
MH  - Killer Cells, Natural/metabolism
MH  - Macrophages/metabolism
MH  - Models, Biological
MH  - Receptors, Interleukin-2/*biosynthesis
MH  - T-Lymphocytes/*metabolism
MH  - T-Lymphocytes, Regulatory/*metabolism
MH  - Transforming Growth Factor beta/metabolism
RF  - 89
EDAT- 2005/12/22 09:00
MHDA- 2006/06/03 09:00
CRDT- 2005/12/22 09:00
PHST- 2005/12/22 09:00 [pubmed]
PHST- 2006/06/03 09:00 [medline]
PHST- 2005/12/22 09:00 [entrez]
AID - 1889 [pii]
AID - 10.2741/1889 [doi]
PST - epublish
SO  - Front Biosci. 2006 May 1;11:1360-70. doi: 10.2741/1889.