PMID- 16370570
OWN - NLM
STAT- MEDLINE
DCOM- 20060126
LR  - 20191026
IS  - 0391-4097 (Print)
IS  - 0391-4097 (Linking)
VI  - 28
IP  - 9
DP  - 2005 Oct
TI  - Type 2 diabetes mellitus in children and adolescents.
PG  - 853-63
AB  - Over the last decade, there has been an alarming increase of Type 2 diabetes 
      mellitus (T2DM) in youths, concomitant with the rise of obesity in this age 
      group. T2DM is a progressive disease with a gradual increase in insulin 
      resistance associated later with a decline in insulin secretion with fasting 
      hyperglycemia. Prevalence of T2DM in children is mostly linked to some risk 
      factors: obesity and sedentary lifestyle, puberty, membership of ethnic 
      minorities, features of insulin resistance, family history of T2DM, female gender 
      and perinatal factors. Prevention is essential and can be considered a public 
      health approach directed to the general population. Treatment of T2DM in youth is 
      complex and based on different strategies: diet, exercise and pharmacotherapy. An 
      appropriated intervention program must be started early, in order to prevent or 
      retard the progression of the disease and associated comorbidities.
FAU - Marcovecchio, M
AU  - Marcovecchio M
AD  - Department of Pediatrics, University of Chieti, Italy.
FAU - Mohn, A
AU  - Mohn A
FAU - Chiarelli, F
AU  - Chiarelli F
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
SB  - IM
MH  - Acanthosis Nigricans/epidemiology
MH  - Adolescent
MH  - Child
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/*drug therapy/*epidemiology/physiopathology/*prevention 
      & control
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Life Style
MH  - Male
MH  - Obesity/complications
MH  - Polycystic Ovary Syndrome/epidemiology/etiology
MH  - Puberty
MH  - Risk Factors
MH  - Sex Factors
RF  - 79
EDAT- 2005/12/24 09:00
MHDA- 2006/01/27 09:00
CRDT- 2005/12/24 09:00
PHST- 2005/12/24 09:00 [pubmed]
PHST- 2006/01/27 09:00 [medline]
PHST- 2005/12/24 09:00 [entrez]
AID - 3096 [pii]
AID - 10.1007/BF03347581 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2005 Oct;28(9):853-63. doi: 10.1007/BF03347581.