PMID- 16371110
OWN - NLM
STAT- MEDLINE
DCOM- 20060413
LR  - 20061115
IS  - 0105-6263 (Print)
IS  - 0105-6263 (Linking)
VI  - 29
IP  - 1
DP  - 2006 Feb
TI  - In utero exposure to persistent organic pollutants in relation to testicular 
      cancer risk.
PG  - 228-34
AB  - Testicular cancer is the most common tumour type in young men. In Sweden the 
      annual age-adjusted incidence increased significantly by 2.4% during the time 
      period 1984-1993 and during 1994-2003 by 1.4%. Exposure to endocrine disrupting 
      chemicals during the foetal period has been postulated to be a risk factor. In 
      this investigation we studied the concentrations of chlorinated biphenyls (PCBs), 
      p,p'-dichlorodiphenyl-dichloroethylene (pp'-DDE), hexachlorobenzene (HCB), 
      chlordanes and polybrominated diphenylethers (PBDEs) in 58 cases with testicular 
      cancer and 61 age-matched controls. Furthermore, case and control mothers were 
      also asked to participate and 44 case mothers and 45 control mothers agreed. No 
      significant differences were found between cases and controls. Case mothers had 
      in general higher concentrations of these chemicals. For the sum of PCBs an odds 
      ratio (OR) = 3.8, 95% confidence interval (CI) = 1.4-10 was calculated using the 
      median concentration for the controls as cut-off value. For HCB OR = 4.4, CI = 
      1.7-12 and for PBDE OR = 2.5, 95% CI = 1.02-6.0 were obtained, whereas OR was not 
      significantly increased for pp'-DDE and sum of chlordanes. The cases were born 
      during a period with high concentrations of persistent organic pollutants (POPs) 
      in humans. The decline of the increasing incidence of testicular cancer during 
      recent years may reflect decreasing body burden of certain POPs since the 1980s.
FAU - Hardell, Lennart
AU  - Hardell L
AD  - Department of Oncology, University Hospital, S-701 85 Orebro, Sweden. 
      lennart.hardell@orebroll.se
FAU - Bavel, Bert
AU  - Bavel B
FAU - Lindstrom, Gunilla
AU  - Lindstrom G
FAU - Eriksson, Mikael
AU  - Eriksson M
FAU - Carlberg, Michael
AU  - Carlberg M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051220
PL  - England
TA  - Int J Androl
JT  - International journal of andrology
JID - 8000141
RN  - 0 (Organic Chemicals)
SB  - IM
MH  - Case-Control Studies
MH  - Confidence Intervals
MH  - *Environmental Exposure
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Odds Ratio
MH  - Organic Chemicals/blood/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Regression Analysis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Testicular Neoplasms/*chemically induced/epidemiology
EDAT- 2005/12/24 09:00
MHDA- 2006/04/14 09:00
CRDT- 2005/12/24 09:00
PHST- 2005/12/24 09:00 [pubmed]
PHST- 2006/04/14 09:00 [medline]
PHST- 2005/12/24 09:00 [entrez]
AID - IJA622 [pii]
AID - 10.1111/j.1365-2605.2005.00622.x [doi]
PST - ppublish
SO  - Int J Androl. 2006 Feb;29(1):228-34. doi: 10.1111/j.1365-2605.2005.00622.x. Epub 
      2005 Dec 20.