PMID- 16372071
OWN - NLM
STAT- MEDLINE
DCOM- 20060216
LR  - 20081121
IS  - 1473-0197 (Print)
IS  - 1473-0189 (Linking)
VI  - 6
IP  - 1
DP  - 2006 Jan
TI  - Fabrication and characterization of poly(methylmethacrylate) microfluidic devices 
      bonded using surface modifications and solvents.
PG  - 66-73
AB  - The fabrication of polymer microchips allows inexpensive, durable, 
      high-throughput and disposable devices to be made. Poly(methylmethacrylate) 
      (PMMA) microchips have been fabricated by hot embossing microstructures into the 
      substrate followed by bonding a cover plate. Different surface modifications have 
      been examined to enhance substrate and cover plate adhesion, including: air 
      plasma treatment, and both acid catalyzed hydrolysis and aminolysis of the 
      acrylate to yield carboxyl and amine-terminated PMMA surfaces. Unmodified PMMA 
      surfaces were also studied. The substrate and cover plate adhesion strengths were 
      found to increase with the hydrophilicity of the PMMA surface and reached a peak 
      at 600 kN m(-2) for plasma treated PMMA. A solvent assisted system has also been 
      designed to soften less than 50 nm of the surface of PMMA during bonding, while 
      still maintaining microchannel integrity. The extent to which both surface 
      modifications and solvent treatment affected the adhesion of the substrate to the 
      cover plate was examined using nanoindentation methods. The solvent bonding 
      system greatly increased the adhesion strengths for both unmodified and modified 
      PMMA, with a maximum adhesion force of 5500 kN m(-2) achieved for unmodified PMMA 
      substrates. The bond strength decreased with increasing surface hydrophilicity 
      after solvent bonding, a trend that was opposite to what was observed for 
      non-solvent thermal bonding.
FAU - Brown, Laurie
AU  - Brown L
AD  - Department of Chemistry, Queen's University, Kingston, Ontario, Canada K7L 3N6.
FAU - Koerner, Terry
AU  - Koerner T
FAU - Horton, J Hugh
AU  - Horton JH
FAU - Oleschuk, Richard D
AU  - Oleschuk RD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051205
PL  - England
TA  - Lab Chip
JT  - Lab on a chip
JID - 101128948
RN  - 0 (Solvents)
RN  - 9011-14-7 (Polymethyl Methacrylate)
SB  - IM
MH  - Equipment Design/methods
MH  - Evaluation Studies as Topic
MH  - Hot Temperature
MH  - Microfluidic Analytical Techniques/*instrumentation/*methods
MH  - Polymethyl Methacrylate/*chemistry
MH  - Solvents/*chemistry
MH  - Surface Properties
EDAT- 2005/12/24 09:00
MHDA- 2006/02/17 09:00
CRDT- 2005/12/24 09:00
PHST- 2005/12/24 09:00 [pubmed]
PHST- 2006/02/17 09:00 [medline]
PHST- 2005/12/24 09:00 [entrez]
AID - 10.1039/b512179e [doi]
PST - ppublish
SO  - Lab Chip. 2006 Jan;6(1):66-73. doi: 10.1039/b512179e. Epub 2005 Dec 5.