PMID- 16372517 OWN - NLM STAT- MEDLINE DCOM- 20060503 LR - 20190608 IS - 0946-1965 (Print) IS - 0946-1965 (Linking) VI - 43 IP - 12 DP - 2005 Dec TI - Acute pancreatitis associated with omeprazole. PG - 558-61 AB - Since their introduction in the late 1980s, proton pump inhibitors (PPI) have demonstrated gastric acid suppression superior to that of histamine H2-receptor blockers. This class of drugs has improved the treatment of various acid-peptic disorders, including gastroesophageal reflux disease, peptic ulcer disease, and nonsteroidal anti-inflammatory drug-induced gastropathy. PPIs have minimal side effects and few significant drug interactions. They are generally considered safe for long-term treatment. We present a rare side effect, acute pancreatitis, occurring in a patient who was treated with the proton pump inhibitor omeprazole. FAU - Youssef, S S AU - Youssef SS AD - James H. Quillen Veterans Affairs and James H. Quillen College of Medicine, Johnson City, TN, USA. FAU - Iskandar, S B AU - Iskandar SB FAU - Scruggs, J AU - Scruggs J FAU - Roy, T M AU - Roy TM LA - eng PT - Case Reports PT - Journal Article PL - Germany TA - Int J Clin Pharmacol Ther JT - International journal of clinical pharmacology and therapeutics JID - 9423309 RN - 0 (Anti-Ulcer Agents) RN - 0 (Enzyme Inhibitors) RN - 0 (Proton Pump Inhibitors) RN - KG60484QX9 (Omeprazole) SB - IM MH - Aged, 80 and over MH - Anti-Ulcer Agents/*adverse effects MH - Enzyme Inhibitors/*adverse effects MH - Humans MH - Male MH - Omeprazole/*adverse effects MH - Pancreatitis/*chemically induced MH - Proton Pump Inhibitors EDAT- 2005/12/24 09:00 MHDA- 2006/05/04 09:00 CRDT- 2005/12/24 09:00 PHST- 2005/12/24 09:00 [pubmed] PHST- 2006/05/04 09:00 [medline] PHST- 2005/12/24 09:00 [entrez] AID - 10.5414/cpp43558 [doi] PST - ppublish SO - Int J Clin Pharmacol Ther. 2005 Dec;43(12):558-61. doi: 10.5414/cpp43558.