PMID- 16375115
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20181203
VI  - 19
IP  - 18
DP  - 2005 Sep
TI  - [Expression and biological significance of survivin and p63 in laryngeal squamous 
      cell carcinoma].
PG  - 833-5
AB  - OBJECTIVE: To investigate the expression of Survivin and p63 and their biological 
      significance in laryngeal squamous cell carcinomas (LSCC). METHOD: The expression 
      of Survivin and p63 in 47 cases of tumor tissues, adjacent and normal tissues 
      were detected using in situ hybridization. RESULT: Percentage of Survivin 
      expression was 59.6% (28/47), 25.5% (12/47) in tumor tissues and adjacent tissues 
      respectively. In contrast, normal laryngeal tissues did not express Survivin. 
      Over expression of Survivin was strongly associated with tumor grade, TNM stage 
      and cervical nodal metastasis. Percentage of p63 expression was 91.5% (43/47), 
      93.6% (44/47), 57.1% (8/14) in tumor tissues, adjacent and normal tissues 
      respectively. The expression of p63 was not related to any clinicopathological 
      features. CONCLUSION: Survivin may play an important role in the pathway of 
      carcinogenesis and progression of LSCC and it may be identified as a new 
      therapeutic target. The up-regulation of the expression of Survivin predicts more 
      invasion and poor prognosis. p63 has less effect on biological behaviors of LSCC.
FAU - Wen, Xiaoxia
AU  - Wen X
AD  - Department of Otolaryngology, the Fourth Affiliated Hospital of China Medical 
      University, Shenyang, 110032, China. wenxinger@sina.com
FAU - Gao, Ying
AU  - Gao Y
FAU - Ji, Wenyue
AU  - Ji W
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (BIRC5 protein, human)
RN  - 0 (CKAP4 protein, human)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Survivin)
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Membrane Proteins/*metabolism
MH  - Microtubule-Associated Proteins/*metabolism
MH  - Middle Aged
MH  - Survivin
EDAT- 2005/12/27 09:00
MHDA- 2011/04/08 06:00
CRDT- 2005/12/27 09:00
PHST- 2005/12/27 09:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
PHST- 2005/12/27 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Sep;19(18):833-5.