PMID- 1637520
OWN - NLM
STAT- MEDLINE
DCOM- 19920901
LR  - 20190510
IS  - 0895-7061 (Print)
IS  - 0895-7061 (Linking)
VI  - 5
IP  - 7
DP  - 1992 Jul
TI  - Effects of dietary fish oil on Rb+ efflux from aorta of stroke prone 
      spontaneously hypertensive rats.
PG  - 473-9
AB  - The effect of fish oil on potassium efflux and basal tension in aortas from 
      stroke prone spontaneously hypertensive rats (SHRSP) was evaluated. Four-week-old 
      male Wistar-Kyoto rats (WKY) and SHRSP were divided into two groups: one received 
      a 5% corn oil diet; the other a 5% menhaden oil diet. After 15 weeks, mean 
      systolic blood pressure (mm Hg) was reduced in SHRSP-fish (202 +/- 5) compared to 
      SHRSP-corn (227 +/- 4). Systolic pressure of WKY-fish (146 +/- 3) was not 
      different from WKY-corn (151 +/- 4). Potassium efflux was evaluated with the 
      isotope 86Rb. Basal 86Rb efflux from aorta of SHRSP-corn was evaluated compared 
      to WKY-corn. Diltiazem or sodium nitroprusside decreased 86Rb efflux and basal 
      tension in SHRSP. Basal 86Rb efflux, tension, and the magnitude of this 
      diltiazem- or nitroprusside-induced inhibition were decreased in SHRSP-fish. At 
      maximal diltiazem or nitroprusside concentration, 86Rb efflux from both SHRSP 
      dietary groups was similar but still greater than control aorta. The IC50 values 
      for diltiazem or nitroprusside effects on 86Rb efflux and tension were not 
      altered by diet in SHRSP. Qualitatively similar changes in basal 86Rb efflux and 
      tension were noted in WKY-fish compared to WKY-corn. These experiments 
      demonstrate that dietary fish oil supplementation decreased calcium-sensitive 
      86Rb efflux and basal tension in vascular smooth muscle and suggest that these 
      changes may contribute to the concomitant antihypertensive effect of dietary fish 
      oil in SHRSP.
FAU - Smith, J M
AU  - Smith JM
AD  - Department of Physiology, Chicago College of Osteopathic Medicine, Downers Grove, 
      IL 60515.
FAU - Paulson, D J
AU  - Paulson DJ
FAU - Labak, S
AU  - Labak S
LA  - eng
GR  - 2S07 RR05972-02/RR/NCRR NIH HHS/United States
GR  - DK 39200/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Hypertens
JT  - American journal of hypertension
JID - 8803676
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Fish Oils)
RN  - 169D1260KM (Nitroprusside)
RN  - EE92BBP03H (Diltiazem)
RN  - MLT4718TJW (Rubidium)
SB  - IM
MH  - Animals
MH  - Aorta/*metabolism
MH  - Blood Pressure/*drug effects
MH  - Dietary Fats, Unsaturated/*pharmacology
MH  - Diltiazem/pharmacology
MH  - Fish Oils/*pharmacology
MH  - Male
MH  - Nitroprusside/pharmacology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Rubidium/*pharmacokinetics
MH  - Vasoconstriction/drug effects
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
AID - 10.1093/ajh/5.7.473 [doi]
PST - ppublish
SO  - Am J Hypertens. 1992 Jul;5(7):473-9. doi: 10.1093/ajh/5.7.473.