PMID- 16375661
OWN - NLM
STAT- MEDLINE
DCOM- 20060307
LR  - 20191026
IS  - 1567-2050 (Print)
IS  - 1567-2050 (Linking)
VI  - 2
IP  - 5
DP  - 2005 Dec
TI  - MRI abnormalities associated with mild cognitive impairments of vascular (VMCI) 
      versus neurodegenerative (NMCI) types prodromal for vascular and Alzheimer's 
      dementias.
PG  - 579-85
AB  - BACKGROUND AND OBJECTIVES: Mild Cognitive Impairments (MCIs) are identifiable 
      clinical entities, in neurodegenerative forms, as prodromal for Alzheimer's type 
      (DAT) or in vascular forms, as prodromal for vascular dementia (VaD). The present 
      longitudinal study compares and contrasts MRI abnormalities among MCI subjects as 
      they progress to DAT versus VaD. Subjects converting to DAT and VaD confirmed 
      ultimate diagnosis during MCI staging. In "mixed cases" the predominant MRI 
      pathology was judged the primary cause. SUBJECTS AND METHODS: Subjects (n = 153) 
      were selected from elderly outpatient volunteers who have been enrolled for 25 
      years in planned longitudinal studies of aging, stroke and dementia. Cognitively 
      normal (CN, n = 52), MCI of neurodegenerative (N-MCI, n = 30) and vascular 
      (V-MCI), n = 35) subtypes, plus converted DAT (n = 19) and VaD (n = 17) were 
      diagnosed according to established protocols. Combined Mini-Mental-Cognitive 
      Capacity Screening Examinations (CMC) screened, identified and confirmed MCIs or 
      dementias. Cerebral MRI abnormalities were analyzed utilizing volumetric 
      measurements and visual rating scales. RESULTS: Compared with persistently 
      cognitively normal subjects, MCI subjects and converted dementias were 
      significantly older without significant gender differences, but cognitively 
      impaired subjects were older than the CN group since age is a risk factor for 
      cognitive decline. Histories of hypertension, heart disease, diabetes mellitus, 
      TIAs and strokes were more frequent among subjects with VMCI and VaD, confirming 
      that all vascular risk factors contribute to vascular cognitive decline, but 
      since vascular risk factors were treated, not all progressed to VAD. Family 
      history of neurodegenerative disease, particularly DAT, were more prevalent among 
      NMCI and converted DAT subjects. VMCI showed more extensive leucoaraiosis and 
      lacunar infarcts than subjects with NMCI. NMCI, prodromal for dementia of 
      Alzheimer's type (DAT), showed more medial temporal lobe atrophy with enlarged 
      temporal horns, and fewer vascular lesions.
FAU - Meyer, John Stirling
AU  - Meyer JS
AD  - Department of Neurology, Baylor College of Medicine, Michael E. DeBakey Veterans 
      Administration Medical Center, Houston, Texas 77030, USA. jmeyer@bcm.tmc.edu
FAU - Huang, Juebin
AU  - Huang J
FAU - Chowdhury, Munir
AU  - Chowdhury M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United Arab Emirates
TA  - Curr Alzheimer Res
JT  - Current Alzheimer research
JID - 101208441
SB  - IM
CIN - Curr Alzheimer Res. 2005 Dec;2(5):495-6. PMID: 16375652
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*pathology
MH  - Cognition Disorders/*pathology
MH  - Dementia, Vascular/*pathology
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Degeneration/pathology
MH  - Neuropsychological Tests
MH  - Severity of Illness Index
EDAT- 2005/12/27 09:00
MHDA- 2006/03/08 09:00
CRDT- 2005/12/27 09:00
PHST- 2005/12/27 09:00 [pubmed]
PHST- 2006/03/08 09:00 [medline]
PHST- 2005/12/27 09:00 [entrez]
AID - 10.2174/156720505774932241 [doi]
PST - ppublish
SO  - Curr Alzheimer Res. 2005 Dec;2(5):579-85. doi: 10.2174/156720505774932241.