PMID- 16375693
OWN - NLM
STAT- MEDLINE
DCOM- 20060120
LR  - 20211203
IS  - 1568-0088 (Print)
IS  - 1568-0088 (Linking)
VI  - 5
IP  - 4
DP  - 2005 Dec
TI  - The new immunosuppression: intervention at the dendritic cell-T-cell interface.
PG  - 397-411
AB  - Dendritic cells (DCs) play an important role in initiating and directing T-cells 
      towards immunity or tolerance. An important aim of emerging immunosuppressive 
      strategies is to ensure that antigen is perceived in a 'tolerogenic context'. 
      This would have obvious benefit in minimising the need for long-term drug 
      maintenance in organ transplantation, hypersensitivity and autoimmune diseases. 
      Here we review the biology of the interplay between the DC and T-cell, with a 
      specific focus on therapeutic drugs targeting molecules that effect their 
      interaction and function.
FAU - Paterson, A M
AU  - Paterson AM
AD  - Sir William Dunn School of Pathology, University of Oxford, South Parks Road, UK. 
      alison.paterson@path.ox.ac.uk
FAU - Yates, S F
AU  - Yates SF
FAU - Nolan, K F
AU  - Nolan KF
FAU - Waldmann, H
AU  - Waldmann H
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Drug Targets Immune Endocr Metabol Disord
JT  - Current drug targets. Immune, endocrine and metabolic disorders
JID - 101121150
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/*pharmacology
MH  - Dendritic Cells/drug effects/*immunology
MH  - Graft Rejection/immunology/prevention & control
MH  - Humans
MH  - Immune Tolerance
MH  - *Immunosuppression Therapy
MH  - Immunosuppressive Agents/*pharmacology
MH  - T-Lymphocytes/drug effects/*immunology
RF  - 222
EDAT- 2005/12/27 09:00
MHDA- 2006/01/21 09:00
CRDT- 2005/12/27 09:00
PHST- 2005/12/27 09:00 [pubmed]
PHST- 2006/01/21 09:00 [medline]
PHST- 2005/12/27 09:00 [entrez]
AID - 10.2174/156800805774912935 [doi]
PST - ppublish
SO  - Curr Drug Targets Immune Endocr Metabol Disord. 2005 Dec;5(4):397-411. doi: 
      10.2174/156800805774912935.