PMID- 16376611
OWN - NLM
STAT- MEDLINE
DCOM- 20061212
LR  - 20181201
IS  - 1388-9842 (Print)
IS  - 1388-9842 (Linking)
VI  - 8
IP  - 5
DP  - 2006 Aug
TI  - Effect of beta-blocker therapy on functional status in patients with heart 
      failure--a meta-analysis.
PG  - 522-31
AB  - BACKGROUND: The results of randomised control trials (RCTs) evaluating the effect 
      of beta-blockers on functional status in patients with chronic heart failure are 
      conflicting. AIM: To perform a systematic review and meta-analysis of RCTs 
      evaluating the effect of beta-blockers on New York Heart Association (NYHA) 
      classification and exercise tolerance in chronic heart failure. METHODS AND 
      RESULTS: We selected 28 RCTs evaluating beta-blocker versus placebo in addition 
      to ACE inhibitor therapy. Combined results of 23 RCTs showed that beta-blockers 
      improved NYHA class by at least one class with odds ratio (OR) 1.80 (1.33-2.43) 
      p<0.0001. Meta-analysis of 10 RCTs showed a significant prolongation of exercise 
      time by 44.19 (6.62-81.75) s p=0.021. Combining 8 RCTs evaluating the maximal 
      peak oxygen uptake and 9 RCTs evaluating 6-min walk distance showed that 
      beta-blockers had no significant effect compared with placebo, p=0.484, and 
      p=0.730, respectively. Combined results of the 23 RCTs showed significant 
      reducing effect on all cause mortality with OR=0.69 (0.59-0.82) p<0.0001. 
      CONCLUSION: Chronic use of a beta-blocker in conjunction with ACE inhibitor 
      therapy improves dyspnoea and prolongs exercise tolerance time, but has no 
      significant effect on 6-min walk test or maximal oxygen uptake in patients with 
      heart failure.
FAU - Abdulla, Jawdat
AU  - Abdulla J
AD  - Department of Cardiology, Gentofte University Hospital, Copenhagen, Denmark. 
      ja@heart.dk
FAU - Kober, Lars
AU  - Kober L
FAU - Christensen, Erik
AU  - Christensen E
FAU - Torp-Pedersen, Christian
AU  - Torp-Pedersen C
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20051222
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0 (Adrenergic beta-Antagonists)
SB  - IM
MH  - Adrenergic beta-Antagonists/*therapeutic use
MH  - Exercise Test
MH  - *Exercise Tolerance/drug effects
MH  - Heart Failure/*drug therapy/mortality/*physiopathology
MH  - Humans
MH  - Oxygen Consumption/drug effects
MH  - Randomized Controlled Trials as Topic
MH  - Treatment Outcome
EDAT- 2005/12/27 09:00
MHDA- 2006/12/13 09:00
CRDT- 2005/12/27 09:00
PHST- 2005/04/28 00:00 [received]
PHST- 2005/06/25 00:00 [revised]
PHST- 2005/10/17 00:00 [accepted]
PHST- 2005/12/27 09:00 [pubmed]
PHST- 2006/12/13 09:00 [medline]
PHST- 2005/12/27 09:00 [entrez]
AID - S1388-9842(05)00292-8 [pii]
AID - 10.1016/j.ejheart.2005.10.012 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2006 Aug;8(5):522-31. doi: 10.1016/j.ejheart.2005.10.012. Epub 
      2005 Dec 22.