PMID- 16379651
OWN - NLM
STAT- MEDLINE
DCOM- 20060712
LR  - 20220317
IS  - 0002-9645 (Print)
IS  - 0002-9645 (Linking)
VI  - 66
IP  - 12
DP  - 2005 Dec
TI  - Assessment of plasma brain natriuretic peptide concentration in Boxers with 
      arrhythmogenic right ventricular cardiomyopathy.
PG  - 2086-9
AB  - OBJECTIVE: To determine whether Boxers with a clinical diagnosis of 
      arrhythmogenic right ventricular cardiomyopathy (ARVC) have increased plasma 
      concentrations of brain natriuretic peptide (BNP), compared with concentrations 
      in clinically normal dogs. ANIMALS: 13 Boxers with ARVC, 9 clinically normal 
      Boxers, 10 clinically normal non-Boxer dogs, and 5 hound dogs with systolic 
      dysfunction. PROCEDURE: All Boxers were evaluated via 24-hour ambulatory 
      electrocardiography and echocardiography; the number of ventricular premature 
      contractions (VPCs) per 24 hours was assessed. Hound dogs with cardiac 
      pacing-induced systolic dysfunction (positive control dogs) and clinically normal 
      non-Boxer dogs (negative control dogs) were evaluated echocardiographically. 
      Three milliliters of blood was collected from each dog for measurement of plasma 
      BNP concentration by use of a radioimmunoassay. RESULTS: Mean +/- SD plasma BNP 
      concentration for the ARVC-affected Boxers, clinically normal Boxers, negative 
      control dogs, and positive control dogs was 11.0 +/- 4.6 pg/mL, 7.9 +/- 3.2 
      pg/mL, 11.5 +/- 4.9 pg/mL, and 100.8 +/- 56.8 pg/mL, respectively. Compared with 
      findings in the positive control group, plasma BNP concentration in each of the 
      other 3 groups was significantly different. There was no significant difference 
      in BNP concentration between the 2 groups of Boxers. A significant correlation 
      between plasma BNP concentration and number of VPCs per 24 hours in the 
      ARVC-affected Boxers was not identified. CONCLUSIONS AND CLINICAL RELEVANCE: A 
      significant difference in BNP concentration between Boxers with ARVC and 
      clinically normal Boxers was not identified. Results suggest that BNP 
      concentration may not be an indicator of ARVC in Boxers.
FAU - Baumwart, Ryan D
AU  - Baumwart RD
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The 
      Ohio State University, Columbus, OH 43210, USA.
FAU - Meurs, Kathryn M
AU  - Meurs KM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Vet Res
JT  - American journal of veterinary research
JID - 0375011
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Animals
MH  - Arrhythmogenic Right Ventricular Dysplasia/blood/*veterinary
MH  - Dog Diseases/*blood
MH  - Dogs
MH  - Echocardiography/veterinary
MH  - Electrocardiography/veterinary
MH  - Natriuretic Peptide, Brain/*blood
MH  - Radioimmunoassay/veterinary
EDAT- 2005/12/29 09:00
MHDA- 2006/07/13 09:00
CRDT- 2005/12/29 09:00
PHST- 2005/12/29 09:00 [pubmed]
PHST- 2006/07/13 09:00 [medline]
PHST- 2005/12/29 09:00 [entrez]
AID - 10.2460/ajvr.2005.66.2086 [doi]
PST - ppublish
SO  - Am J Vet Res. 2005 Dec;66(12):2086-9. doi: 10.2460/ajvr.2005.66.2086.