PMID- 16380692
OWN - NLM
STAT- MEDLINE
DCOM- 20060602
LR  - 20131121
IS  - 0172-780X (Print)
IS  - 0172-780X (Linking)
VI  - 26
IP  - 6
DP  - 2005 Dec
TI  - Neonatal hypothyroidism-induced changes in rat testis size, dependence on 
      temperature.
PG  - 780-8
AB  - OBJECTIVE: Effects of transient neonatal hypothyroidism (HPOT) on adult testis 
      size and serum hormone profiles were evaluated in the Charles foster strain of 
      rats, maintained under the temperature of 21 degrees C (HPOTL) or of 34 degrees C 
      (HPOTH). METHODS: Hypothyroidism was induced in suckling pups in preweanling 
      period (1-21 days), by administering 0.1% 6-propyl-2-thiouracil in drinking water 
      to mothers. Body mass and testis characteristics, the steroidogenic potential 
      [measured by histochemical localization of 3alpha-, 3beta- and 
      17beta-hydroxysteroid dehydrogenases (HSDHs)] and serum concentrations of 
      thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), 
      luteinizing hormone (LH), testosterone (T) and corticosterone (Cort) were 
      evaluated on the 35th, 45th, 60th and 90th day of age. RESULTS: The HPOTH rats 
      showed lower testis masses, while the HPOTL rats showed higher testis masses and 
      lower body masses after 90 days. Histologically, the testes of the HPOTH rats 
      demonstrated increased germ cell degeneration after 35 and 45 days and reduced 
      tubular size, germ cell numbers and sperm density after 90 days. In contrast, the 
      testes of the HPOTL rats showed reduced tubular diameters after 35 and 45 days, 
      and increased tubular diameters, germ cell numbers and sperm density after 90 
      days. Serum TSH, T3, T4, LH and T concentrations and 3beta- and 17beta-HSDH 
      activities were reduced in both groups of the HPOT rats after 35 and 45 days. 
      Intratubular steroidogenesis and a prominent triangle up5 pathway were also found 
      in the HPOT animals. CONCLUSION: The temperature has a definite influence on the 
      thyroid hormone action, postnatal growth and function of rat testes.
FAU - Lagu, S K
AU  - Lagu SK
AD  - Division of Reproductive Biology and Endocrinology, Department of Zoology, 
      Faculty of Science, M. S. University of Baroda, Vadodara.390 002, Gujarat, India.
FAU - Bhavsar, N G
AU  - Bhavsar NG
FAU - Sharma, R K
AU  - Sharma RK
FAU - Ramachandran, A V
AU  - Ramachandran AV
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Sweden
TA  - Neuro Endocrinol Lett
JT  - Neuro endocrinology letters
JID - 8008373
RN  - 0 (Thyroid Hormones)
RN  - 721M9407IY (Propylthiouracil)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 9002-71-5 (Thyrotropin)
RN  - EC 1.1.- (Hydroxysteroid Dehydrogenases)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn/physiology
MH  - Body Weight/physiology
MH  - Corticosterone/blood
MH  - Female
MH  - Germ Cells/cytology
MH  - Hydroxysteroid Dehydrogenases/metabolism
MH  - Hypothyroidism/chemically induced/*physiopathology
MH  - Luteinizing Hormone/blood
MH  - Male
MH  - Organ Size
MH  - Pregnancy
MH  - Propylthiouracil
MH  - Rats
MH  - Temperature
MH  - Testis/cytology/enzymology/*growth & development
MH  - Thyroid Hormones/*blood
MH  - Thyrotropin/blood
EDAT- 2005/12/29 09:00
MHDA- 2006/06/03 09:00
CRDT- 2005/12/29 09:00
PHST- 2004/03/15 00:00 [received]
PHST- 2005/01/19 00:00 [accepted]
PHST- 2005/12/29 09:00 [pubmed]
PHST- 2006/06/03 09:00 [medline]
PHST- 2005/12/29 09:00 [entrez]
AID - NEL260605A20 [pii]
PST - ppublish
SO  - Neuro Endocrinol Lett. 2005 Dec;26(6):780-8.