PMID- 16382212
OWN - NLM
STAT- MEDLINE
DCOM- 20060721
LR  - 20200106
IS  - 1734-1140 (Print)
IS  - 1734-1140 (Linking)
VI  - 57
IP  - 6
DP  - 2005 Nov-Dec
TI  - Plasma concentrations of adhesion molecules and chemokines in patients with 
      essential hypertension.
PG  - 878-81
AB  - Arterial hypertension vascular injury results in serious complications, such as 
      left-ventricular hypertrophy and myocardial failure, ischemic heart disease and 
      cerebral stroke. Currently, it is well known that inflammatory factors play a 
      significant role in the mechanisms that trigger and enhance the remodeling of the 
      vascular wall. A number of data suggest an important role of adhesion molecules 
      and chemokines in this processes. The aim of this study was measuring the plasma 
      levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) and Monocyte 
      Chemoattractant Peptide1 (MCP-1) in patients with essential hypertension vs. 
      healthy volunteers by ELISA method (R&D kits). sICAM-1 and MCP-1 levels were 
      significantly higher in hypertensive patients compared to controls (sICAM-1: 
      279.2 +/- 8.8 ng/ml vs. 224.4 +/- 1.8 ng/ml; p < 0.001; MCP-1: 142.2 +/- 7 pg/ml 
      vs. 95.4 +/- 36 pg/ml; p < 0.0001. Our results indicate that arterial 
      hypertension alone (without inflammation, lipid and carbohydrate disorders) may 
      increase the expression of these cytokines and contribute to the progression of 
      endothelial injury.
FAU - Madej, Andrzej
AU  - Madej A
AD  - Department of Clinical Pharmacology, Silesian University School of Medicine, 
      Medykow 18, PL 40-752 Katowice, Poland. andrzejmadej@o2.pl
FAU - Okopien, Boguslaw
AU  - Okopien B
FAU - Kowalski, Jan
AU  - Kowalski J
FAU - Haberka, Maciej
AU  - Haberka M
FAU - Herman, Zbigniew S
AU  - Herman ZS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Switzerland
TA  - Pharmacol Rep
JT  - Pharmacological reports : PR
JID - 101234999
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Lipids)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Hypertension/*blood
MH  - Intercellular Adhesion Molecule-1/*blood
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
EDAT- 2005/12/31 09:00
MHDA- 2006/07/22 09:00
CRDT- 2005/12/31 09:00
PHST- 2005/01/07 00:00 [received]
PHST- 2005/09/07 00:00 [revised]
PHST- 2005/12/31 09:00 [pubmed]
PHST- 2006/07/22 09:00 [medline]
PHST- 2005/12/31 09:00 [entrez]
PST - ppublish
SO  - Pharmacol Rep. 2005 Nov-Dec;57(6):878-81.