PMID- 16382466
OWN - NLM
STAT- MEDLINE
DCOM- 20060609
LR  - 20061115
IS  - 1527-6465 (Print)
IS  - 1527-6465 (Linking)
VI  - 12
IP  - 1
DP  - 2006 Jan
TI  - Fatal graft-versus-host disease after living donor liver transplantation: 
      differential impact of donor-dominant one-way HLA matching.
PG  - 140-5
AB  - Graft-versus-host disease (GVHD) is an uncommon but potentially devastating 
      complication following liver transplantation. Recently, it was shown that use of 
      a human leukocyte antigen (HLA)-homozygous donor leading to one-way HLA matching 
      significantly increases the risk of GVHD after living donor liver transplantation 
      (LDLT). However, the precise impact of HLA matching between donor and recipient 
      on the risk of GVHD is not yet clear. We surveyed instances of fatal GVHD 
      following LDLT in Japan and reviewed all 8 cases in detail, especially with 
      respect to HLA matching. Serological typing showed that 7 of those cases had 
      donor-dominant one-way HLA matching in the 3 loci of HLA-A, -B, and -DR, while 
      one had donor-dominant one-way HLA matching in the 2 loci of HLA-A and -DR and 
      identical alleles in the B locus. However, DNA typing revealed that the latter 
      case had 1-way HLA matching in the 3 loci. Further, we analyzed HLA typing of 906 
      donor-recipient pairs who underwent LDLT. There were 5 cases with donor-dominant 
      one-way matching in 2 loci and 2 with donor-dominant one-way matching in 1 locus. 
      All of those cases except 1, who died from an unrelated cause, are alive without 
      an obvious presentation of GVHD. In conclusion, our results suggest that the 
      total number of loci with donor-dominant one-way HLA matching is important for 
      determining the risk of fatal GVHD following LDLT, and that DNA typing of HLA 
      alleles is indispensable in some cases to identify the true risk of 
      donor-dominant 1-way HLA matching.
CI  - Copyright 2005 AASLD
FAU - Kamei, Hideya
AU  - Kamei H
AD  - Department of Transplantation Surgery, Nagoya University Hospital, Nagoya, Japan. 
      kamei@med.nagoya-u.ac.jp
FAU - Oike, Fumitaka
AU  - Oike F
FAU - Fujimoto, Yasuhiro
AU  - Fujimoto Y
FAU - Yamamoto, Hidekazu
AU  - Yamamoto H
FAU - Tanaka, Koichi
AU  - Tanaka K
FAU - Kiuchi, Tetsuya
AU  - Kiuchi T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Liver Transpl
JT  - Liver transplantation : official publication of the American Association for the 
      Study of Liver Diseases and the International Liver Transplantation Society
JID - 100909185
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Biopsy, Needle
MH  - *Cause of Death
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Graft Rejection
MH  - Graft vs Host Disease/*mortality/pathology
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Immunohistochemistry
MH  - Infant
MH  - Japan
MH  - Liver Failure/diagnosis/surgery
MH  - Liver Transplantation/*immunology/*mortality
MH  - *Living Donors
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Survival Rate
EDAT- 2005/12/31 09:00
MHDA- 2006/06/10 09:00
CRDT- 2005/12/31 09:00
PHST- 2005/12/31 09:00 [pubmed]
PHST- 2006/06/10 09:00 [medline]
PHST- 2005/12/31 09:00 [entrez]
AID - 10.1002/lt.20573 [doi]
PST - ppublish
SO  - Liver Transpl. 2006 Jan;12(1):140-5. doi: 10.1002/lt.20573.