PMID- 1638492
OWN - NLM
STAT- MEDLINE
DCOM- 19920901
LR  - 20190815
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 61
IP  - 2
DP  - 1992 Jul 15
TI  - Analysis of a giant marker chromosome in a well-differentiated liposarcoma using 
      cytogenetics and fluorescence in situ hybridization.
PG  - 134-8
AB  - Well-differentiated liposarcomas (LPS) are cytogenetically very complex, 
      characterized by giant marker chromosomes, ring chromosomes, and telomeric 
      associations. We report a case of well-differentiated LPS in which the only 
      cytogenetic anomaly was an additional giant marker. In an attempt to identify the 
      origin of this marker, centromeric probes (chosen on the basis of the morphology 
      of the marker) to chromosomes 1,2,3,4,6,7,8,9,10,11,12,16,17, and X and a shared 
      satellite probe for chromosomes 1,5, and 19, were used with fluorescence in situ 
      hybridization (FISH). This was successful at eliminating certain chromosomes as 
      candidates for centromeric trisomy but could not identify the origin of the 
      marker. This case is unusual in that it does not conform to the typical 
      cytogenetic pattern for well-differentiated LPS and is the first known example 
      with an apparently normal diploid karyotype with only one additional change.
FAU - Stephenson, C F
AU  - Stephenson CF
AD  - Cancer Center, Southwest Biomedical Research Institute of Genetrix, Scottsdale 
      85251.
FAU - Berger, C S
AU  - Berger CS
FAU - Leong, S P
AU  - Leong SP
FAU - Davis, J R
AU  - Davis JR
FAU - Sandberg, A A
AU  - Sandberg AA
LA  - eng
GR  - CA-41183/CA/NCI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (DNA Probes)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Aged
MH  - *Chromosome Aberrations
MH  - DNA Probes/genetics
MH  - Fluorescence
MH  - Genetic Markers/*genetics
MH  - Genital Neoplasms, Male/*genetics
MH  - Humans
MH  - Liposarcoma/*genetics
MH  - Male
MH  - Nucleic Acid Hybridization
MH  - Scrotum/*pathology
EDAT- 1992/07/15 00:00
MHDA- 1992/07/15 00:01
CRDT- 1992/07/15 00:00
PHST- 1992/07/15 00:00 [pubmed]
PHST- 1992/07/15 00:01 [medline]
PHST- 1992/07/15 00:00 [entrez]
AID - 0165-4608(92)90075-J [pii]
AID - 10.1016/0165-4608(92)90075-j [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1992 Jul 15;61(2):134-8. doi: 
      10.1016/0165-4608(92)90075-j.