PMID- 16386646
OWN - NLM
STAT- MEDLINE
DCOM- 20060922
LR  - 20111117
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 66
IP  - 10
DP  - 2005 Oct
TI  - HLA alleles and risk of cervical intraepithelial neoplasia among southwestern 
      American Indian women.
PG  - 1050-6
AB  - An increase in cervical intraepithelial neoplasia (CIN) has been described in 
      American Indian women in New Mexico. Differences in human leukocyte antigen (HLA) 
      alleles have been reported in cervical intraepithelial neoplasia (CIN) compared 
      with controls in other populations. We investigated HLA alleles and CIN in 
      Southwest American Indian women. The case control study included 89 women with 
      biopsy-proven CIN II/III (diagnosed November 1994 through October 1997) and 271 
      similar women with normal cervical epithelium from the same clinics. DRB1, DQB1, 
      and DPB1 alleles were determined using DNA typing techniques. DQA1 and HLA-A 
      allele typing was included for some subjects (randomly chosen n = 37 and n = 163 
      cases and controls, respectively). We found a decreased risk of CIN with 
      DRB1*1402 (OR 0.5, 95% CI 0.3-0.9) and an increased risk with DRB1*1501 (OR 2.7, 
      95% CI 0.9-7.3). Additionally, DQA1*0102 was associated with increased risk (OR 
      4.5, 95% CI 1.3-5.3) and HLA-A*02 with decreased risk (OR 0.4, CI 0.2-0.9). Our 
      findings are discussed along with studies in other populations.
FAU - Schiff, Melissa A
AU  - Schiff MA
AD  - Department of Epidemiology, School of Public Health and Community Medicine, 
      University of Washington, Seattle, WA 98104, USA.
FAU - Apple, Raymond J
AU  - Apple RJ
FAU - Lin, Patricia
AU  - Lin P
FAU - Nelson, J Lee
AU  - Nelson JL
FAU - Wheeler, Cosette M
AU  - Wheeler CM
FAU - Becker, Thomas M
AU  - Becker TM
LA  - eng
GR  - R01-CA-55348/CA/NCI NIH HHS/United States
GR  - T32-CA09168/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20051025
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Confidence Intervals
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-A Antigens/*genetics
MH  - HLA-DP Antigens/genetics
MH  - HLA-DP beta-Chains
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Indians, North American
MH  - Membrane Glycoproteins/genetics
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - New Mexico
MH  - Odds Ratio
MH  - Risk Factors
MH  - Uterine Cervical Neoplasms/ethnology/*genetics/pathology
EDAT- 2006/01/03 09:00
MHDA- 2006/09/23 09:00
CRDT- 2006/01/03 09:00
PHST- 2005/03/10 00:00 [received]
PHST- 2005/09/14 00:00 [accepted]
PHST- 2006/01/03 09:00 [pubmed]
PHST- 2006/09/23 09:00 [medline]
PHST- 2006/01/03 09:00 [entrez]
AID - S0198-8859(05)00421-0 [pii]
AID - 10.1016/j.humimm.2005.09.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2005 Oct;66(10):1050-6. doi: 10.1016/j.humimm.2005.09.002. Epub 2005 
      Oct 25.