PMID- 16386650
OWN - NLM
STAT- MEDLINE
DCOM- 20060922
LR  - 20220317
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 66
IP  - 10
DP  - 2005 Oct
TI  - Association of HLA-DR and HLA-DQ genes with susceptibility to pulmonary 
      tuberculosis in Koreans: preliminary evidence of associations with drug 
      resistance, disease severity, and disease recurrence.
PG  - 1074-81
AB  - Only 10% of persons infected with Mycobacterium tuberculosis develop clinical 
      tuberculosis (TB), indicating the existence of host genetic factors regulating 
      disease expression. We investigated the association of human leukocyte antigen 
      (HLA) class II genes with the susceptibility to pulmonary TB in Koreans, with 
      special emphasis on their association with drug resistance, disease severity, and 
      disease recurrence. Human leukocyte antigens (HLA)-DRB1 and -DQB1 gene 
      polymorphisms were analyzed in 160 Korean patients with pulmonary TB and 200 
      ethnically matched healthy controls. HLA-DRB1*0803 (25.0% vs. 14.5% in controls, 
      OR = 1.97, p = 0.012, corrected p (p(c)) > 0.05) and DQB1*0601 (27.5% vs. 15.5% 
      in controls, OR = 2.07, p = 0.005, p(c) > 0.05) were weakly associated with 
      general susceptibility to TB. DRB1*0803 was significantly associated with drug 
      resistance (30.9% vs. 14.5%, OR = 2.63, p(c) = 0.047) and more advanced lung 
      lesion (29.8% vs. 14.5%, OR = 2.50, p(c) = 0.022). DRB1*0803 showed the strongest 
      association with disease recurrence, especially after curative treatment for the 
      earlier infection (47.4% vs. 14.5%, OR = 5.31, p(c) = 0.00009). DQB1*0601, which 
      is strongly linked to DRB1*0803 in this population showed similar changes in the 
      patients as those of DRB1*0803. It is suggested that DRB1*0803 and DQB1*0601 
      alleles are associated with disease progression of TB in Koreans, exerting 
      influence on the development of drug resistance, severe disease, and recurrent 
      disease.
FAU - Kim, Hyun Soo
AU  - Kim HS
AD  - Department of Laboratory Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Park, Myoung Hee
AU  - Park MH
FAU - Song, Eun Young
AU  - Song EY
FAU - Park, Hyejin
AU  - Park H
FAU - Kwon, Sung Youn
AU  - Kwon SY
FAU - Han, Sung Koo
AU  - Han SK
FAU - Shim, Young-Soo
AU  - Shim YS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20051018
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Case-Control Studies
MH  - Confidence Intervals
MH  - Drug Resistance, Bacterial/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Korea
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Recurrence
MH  - Severity of Illness Index
MH  - Tuberculosis, Pulmonary/*genetics/prevention & control
EDAT- 2006/01/03 09:00
MHDA- 2006/09/23 09:00
CRDT- 2006/01/03 09:00
PHST- 2005/07/20 00:00 [received]
PHST- 2005/08/30 00:00 [revised]
PHST- 2005/08/31 00:00 [accepted]
PHST- 2006/01/03 09:00 [pubmed]
PHST- 2006/09/23 09:00 [medline]
PHST- 2006/01/03 09:00 [entrez]
AID - S0198-8859(05)00407-6 [pii]
AID - 10.1016/j.humimm.2005.08.242 [doi]
PST - ppublish
SO  - Hum Immunol. 2005 Oct;66(10):1074-81. doi: 10.1016/j.humimm.2005.08.242. Epub 
      2005 Oct 18.