PMID- 16386651
OWN - NLM
STAT- MEDLINE
DCOM- 20060922
LR  - 20211203
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 66
IP  - 10
DP  - 2005 Oct
TI  - HLA polymorphisms in Cabo Verde and Guine-Bissau inferred from sequence-based 
      typing.
PG  - 1082-92
AB  - Human leukocyte antigen (HLA)-A, -B, and -DRB1 polymorphisms were examined in the 
      Cabo Verde and Guine-Bissau populations. The data were obtained at 
      high-resolution level, using sequence-based typing. The most frequent alleles in 
      each locus was: A*020101 (16.7% in Guine-Bissau and 13.5% in Cabo Verde), 
      B*350101 (14.4% in Guine-Bissau and 13.2% in Cabo Verde), DRB1*1304 (19.6% in 
      Guine-Bissau), and DRB1*1101 (10.1% in Cabo Verde). The predominant three loci 
      haplotype in Guine-Bissau was A*2301-B*1503-DRB1*1101 (4.6%) and in Cabo Verde 
      was A*3002-B*350101-DRB1*1001 (2.8%), exclusive to northwestern islands (5.6%) 
      and absent in Guine-Bissau. The present study corroborates historic sources and 
      other genetic studies that say Cabo Verde were populated not only by Africans but 
      also by Europeans. Haplotypes and dendrogram analysis shows a Caucasian genetic 
      influence in today's gene pool of Cabo Verdeans. Haplotypes and allele 
      frequencies present a differential distribution between southeastern and 
      northwestern Cabo Verde islands, which could be the result of different genetic 
      influences, founder effect, or bottlenecks. Dendrograms and principal coordinates 
      analysis show that Guineans are more similar to North Africans than other 
      HLA-studied sub-Saharans, probably from ancient and recent genetic contacts with 
      other peoples, namely East Africans.
FAU - Spinola, Helder
AU  - Spinola H
AD  - Human Genetics Laboratory, University of Madeira, Campus of Penteada, Funchal, 
      Portugal.
FAU - Bruges-Armas, Jacome
AU  - Bruges-Armas J
FAU - Middleton, Derek
AU  - Middleton D
FAU - Brehm, Antonio
AU  - Brehm A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20051026
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Founder Effect
MH  - Gene Frequency
MH  - Genotype
MH  - Guinea-Bissau
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Phylogeny
MH  - Polymorphism, Genetic
MH  - Racial Groups
MH  - Sequence Analysis, DNA
EDAT- 2006/01/03 09:00
MHDA- 2006/09/23 09:00
CRDT- 2006/01/03 09:00
PHST- 2005/06/15 00:00 [received]
PHST- 2005/08/31 00:00 [accepted]
PHST- 2006/01/03 09:00 [pubmed]
PHST- 2006/09/23 09:00 [medline]
PHST- 2006/01/03 09:00 [entrez]
AID - S0198-8859(05)00420-9 [pii]
AID - 10.1016/j.humimm.2005.09.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2005 Oct;66(10):1082-92. doi: 10.1016/j.humimm.2005.09.001. Epub 
      2005 Oct 26.