PMID- 16386861
OWN - NLM
STAT- MEDLINE
DCOM- 20060420
LR  - 20181203
IS  - 0378-5173 (Print)
IS  - 0378-5173 (Linking)
VI  - 308
IP  - 1-2
DP  - 2006 Feb 3
TI  - Polymeric nanoparticulate delivery system for Indocyanine green: biodistribution 
      in healthy mice.
PG  - 200-4
AB  - The objective of this study is to investigate the biodistribution of Indocyanine 
      green (ICG) in healthy mice, when delivered through polymeric nanoparticles. The 
      poly(DL-lactic-co-glycolic acid) (PLGA) nanoparticles entrapping ICG were 
      engineered and characterized. The extraction method for ICG recovery from 
      biological samples was developed. The biodistribution of ICG was determined in 
      healthy C57BL/6 mice (female, 10-week old) when delivered through PLGA 
      nanoparticles in comparison to free ICG solution, using a fluorometric assay 
      method. The extraction method for ICG shows efficiency above 80% for various 
      organs and plasma. When nanoparticles were used to deliver ICG, 2-8 times higher 
      concentrations of ICG was deposited in various organs, with 5-10 times higher 
      plasma levels till 4 h, after an i.v. dose as compared to free ICG solution. In 
      conclusion, the nanoparticle formulation significantly increased the ICG 
      concentration and circulation time in plasma as well as the ICG uptake, 
      accumulation and retention in various organs. Overall, this study represents the 
      first step in exploring and establishing the potential of nanoparticles as an 
      ICG-delivery system for use in tumor-diagnosis and photodynamic therapy.
FAU - Saxena, Vishal
AU  - Saxena V
AD  - Department of Pharmacy and Administrative Sciences, College of Pharmacy and 
      Allied Health Professions, St. John's University, 8000 Utopia Parkway, Jamaica, 
      NY 11439, USA.
FAU - Sadoqi, Mostafa
AU  - Sadoqi M
FAU - Shao, Jun
AU  - Shao J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Coloring Agents)
RN  - 0 (Glycolates)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Animals
MH  - Coloring Agents/administration & dosage/analysis/pharmacokinetics
MH  - *Drug Delivery Systems
MH  - Female
MH  - Glycolates/*chemistry
MH  - Indocyanine Green/administration & dosage/analysis/*pharmacokinetics
MH  - Injections, Intravenous
MH  - Lactic Acid
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Nanostructures
MH  - Polyglycolic Acid
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/*chemistry
MH  - Reproducibility of Results
MH  - Spectrometry, Fluorescence
MH  - Tissue Distribution
EDAT- 2006/01/03 09:00
MHDA- 2006/04/21 09:00
CRDT- 2006/01/03 09:00
PHST- 2005/06/10 00:00 [received]
PHST- 2005/11/04 00:00 [revised]
PHST- 2005/11/09 00:00 [accepted]
PHST- 2006/01/03 09:00 [pubmed]
PHST- 2006/04/21 09:00 [medline]
PHST- 2006/01/03 09:00 [entrez]
AID - S0378-5173(05)00748-9 [pii]
AID - 10.1016/j.ijpharm.2005.11.003 [doi]
PST - ppublish
SO  - Int J Pharm. 2006 Feb 3;308(1-2):200-4. doi: 10.1016/j.ijpharm.2005.11.003.