PMID- 16387099
OWN - NLM
STAT- MEDLINE
DCOM- 20060302
LR  - 20101118
IS  - 0041-1345 (Print)
IS  - 0041-1345 (Linking)
VI  - 37
IP  - 10
DP  - 2005 Dec
TI  - Lambda light chain deposition disease in a renal allograft.
PG  - 4289-92
AB  - Light chain deposition disease (LCDD) of the kidney is characterized by 
      deposition of monoclonal light chains predominantly in glomeruli and in tubular 
      basement membranes. The disease is frequently associated with a 
      lymphoproliferative disorder, and the majority of cases are caused by deposition 
      of kappa light chains. Although the occurrence of de novo multiple myeloma after 
      renal transplantation is uncommon, there are several reports of LCDD involving 
      renal allografts, either de novo or in patients with a diagnosis of LCDD prior to 
      transplantation. To the best of our knowledge, all previously described cases in 
      allografts have been in patients with kappa chain deposition. The relative 
      importance of intrinsic properties of the kidney in predisposing to either kappa 
      or lambda light chain deposition is not known. We present a case of LCDD caused 
      by deposition of lambda light chains in a patient who received a cadaveric renal 
      transplant.
FAU - Tanenbaum, N D
AU  - Tanenbaum ND
AD  - Division of Nephrology, Duke University Medical Center and Durham VA Medical 
      Center, Durham, North Carolina 27717, USA. tanen001@mc.duke.edu
FAU - Howell, D N
AU  - Howell DN
FAU - Middleton, J P
AU  - Middleton JP
FAU - Spurney, R F
AU  - Spurney RF
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Immunoglobulin Light Chains)
RN  - 0 (Immunoglobulin lambda-Chains)
SB  - IM
MH  - Acute Kidney Injury/etiology
MH  - Aged
MH  - Capillaries/pathology/ultrastructure
MH  - Coronary Artery Bypass
MH  - Glomerular Mesangium/immunology/pathology
MH  - Humans
MH  - Immunoglobulin Light Chains/*analysis
MH  - Immunoglobulin lambda-Chains/*analysis
MH  - Kidney Transplantation/*immunology/*pathology
MH  - Kidney Tubular Necrosis, Acute/complications
MH  - Male
MH  - Paraproteinemias/immunology/pathology
MH  - Renal Circulation
EDAT- 2006/01/03 09:00
MHDA- 2006/03/03 09:00
CRDT- 2006/01/03 09:00
PHST- 2005/06/28 00:00 [received]
PHST- 2006/01/03 09:00 [pubmed]
PHST- 2006/03/03 09:00 [medline]
PHST- 2006/01/03 09:00 [entrez]
AID - S0041-1345(05)01158-9 [pii]
AID - 10.1016/j.transproceed.2005.10.030 [doi]
PST - ppublish
SO  - Transplant Proc. 2005 Dec;37(10):4289-92. doi: 
      10.1016/j.transproceed.2005.10.030.