PMID- 16387291
OWN - NLM
STAT- MEDLINE
DCOM- 20060609
LR  - 20220309
IS  - 0009-8981 (Print)
IS  - 0009-8981 (Linking)
VI  - 366
IP  - 1-2
DP  - 2006 Apr
TI  - A multifaceted molecule, nitric oxide in oral and periodontal diseases.
PG  - 90-100
AB  - Nitric oxide (NO) is a molecule with multiple effects on different tissues. NO 
      takes important roles in vasodilatation, bacterial challenge and cytokine 
      stimulation, regulation of mineralized tissue function, neurotransmission, and 
      platelet aggregation, etc. However, under pathological conditions, NO has 
      damaging effects. NO is synthesized by NO synthases (NOS) and inducible isoform 
      of NOS (iNOS) is closely related to the pathophysiological characteristics of 
      inflammatory diseases such as periodontal diseases. The expression of iNOS has 
      been investigated in salivary gland-related diseases, temporomandibular joint 
      disorders and oral cancer as well. The beneficial and damaging effects of NO in 
      diseases related with periodontal, dental and maxillofacial area are discussed in 
      this review. The biological pathways involved with NO and NO inhibitors may be 
      good drug targets to have a role in the future management of patients with 
      diseases in orofacial region.
FAU - Ugar-Cankal, Dilek
AU  - Ugar-Cankal D
AD  - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi 
      University, Biskek caddesi 84.sokak 06510 Emek, Ankara, Turkey. dugar@gazi.edu.tr
FAU - Ozmeric, Nurdan
AU  - Ozmeric N
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20060104
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 3.5.3.1 (Arginase)
SB  - IM
MH  - Arginase/metabolism
MH  - Humans
MH  - Mouth Diseases/embryology/metabolism/*physiopathology
MH  - Nitric Oxide/biosynthesis/*physiology
MH  - Nitric Oxide Synthase/metabolism
MH  - Periodontal Diseases/enzymology/metabolism/*physiopathology
MH  - Periodontitis/enzymology/metabolism/physiopathology
MH  - Saliva/enzymology/metabolism
RF  - 131
EDAT- 2006/01/03 09:00
MHDA- 2006/06/10 09:00
CRDT- 2006/01/03 09:00
PHST- 2005/09/08 00:00 [received]
PHST- 2005/10/19 00:00 [revised]
PHST- 2005/10/20 00:00 [accepted]
PHST- 2006/01/03 09:00 [pubmed]
PHST- 2006/06/10 09:00 [medline]
PHST- 2006/01/03 09:00 [entrez]
AID - S0009-8981(05)00637-6 [pii]
AID - 10.1016/j.cca.2005.10.018 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2006 Apr;366(1-2):90-100. doi: 10.1016/j.cca.2005.10.018. Epub 
      2006 Jan 4.