PMID- 16387895
OWN - NLM
STAT- MEDLINE
DCOM- 20060619
LR  - 20191109
IS  - 0148-6071 (Print)
IS  - 0148-6071 (Linking)
VI  - 30
IP  - 1
DP  - 2006 Jan-Feb
TI  - A carbohydrate-rich beverage prior to surgery prevents surgery-induced 
      immunodepression: a randomized, controlled, clinical trial.
PG  - 21-6
AB  - BACKGROUND: Fasting before surgery is still common care in a lot of western 
      hospitals. Overnight fasting can induce postoperative insulin resistance. Insulin 
      resistance has been shown to be related to infectious morbidity. It was shown 
      that postoperative insulin resistance can be attenuated by preoperative intake of 
      a clear carbohydrate-rich beverage. The aim of this study was to investigate 
      whether preoperative intake of carbohydrate-rich beverages could postoperatively 
      influence the immune system. METHODS: In this randomized, controlled study, we 
      investigated the effect of surgery on the postoperative immune response in 10 
      preoperatively fasted patients (control) and 2 groups of 10 patients receiving 2 
      different carbohydrate-rich beverages preoperatively, by measuring human 
      leukocyte antigen (HLA)-DR expression on monocytes on the day before and on the 
      day after surgery. Furthermore, we studied perioperative fluid homeostasis and 
      preoperative well-being of the patients. RESULTS: HLA-DR expression decreased 
      significantly after surgery in the control group. Patients receiving any of the 2 
      carbohydrate-rich beverages did not show this postoperative decrease. Fluid 
      homeostasis was not affected in any of the groups, and well-being tended to be 
      better in patients receiving carbohydrate-rich beverages compared with controls. 
      CONCLUSION: This study suggests that preoperative intake of a carbohydrate-rich 
      beverage can prevent surgery-induced immunodepression and thus might reduce the 
      risk of infectious complications.
FAU - Melis, Gerdien C
AU  - Melis GC
AD  - Department of Nutrition Science and Dietetics and Nutritional Team, VU University 
      Medical Center, Amsterdam, The Netherlands. g.melis@vumc.nl
FAU - van Leeuwen, Paul A M
AU  - van Leeuwen PA
FAU - von Blomberg-van der Flier, B Mary E
AU  - von Blomberg-van der Flier BM
FAU - Goedhart-Hiddinga, Andrea C
AU  - Goedhart-Hiddinga AC
FAU - Uitdehaag, Bernard M J
AU  - Uitdehaag BM
FAU - Strack van Schijndel, Rob J M
AU  - Strack van Schijndel RJ
FAU - Wuisman, P I J M
AU  - Wuisman PI
FAU - van Bokhorst-de van der Schueren, Marian A E
AU  - van Bokhorst-de van der Schueren MA
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - JPEN J Parenter Enteral Nutr
JT  - JPEN. Journal of parenteral and enteral nutrition
JID - 7804134
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - *Beverages
MH  - Blood Glucose/metabolism
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Fasting
MH  - Female
MH  - HLA-DR Antigens/analysis/*metabolism
MH  - Humans
MH  - *Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/*prevention & control
MH  - Preoperative Care/*methods
EDAT- 2006/01/03 09:00
MHDA- 2006/06/20 09:00
CRDT- 2006/01/03 09:00
PHST- 2006/01/03 09:00 [pubmed]
PHST- 2006/06/20 09:00 [medline]
PHST- 2006/01/03 09:00 [entrez]
AID - 30/1/21 [pii]
AID - 10.1177/014860710603000121 [doi]
PST - ppublish
SO  - JPEN J Parenter Enteral Nutr. 2006 Jan-Feb;30(1):21-6. doi: 
      10.1177/014860710603000121.