PMID- 16388316
OWN - NLM
STAT- MEDLINE
DCOM- 20060321
LR  - 20191109
IS  - 1219-4956 (Print)
IS  - 1219-4956 (Linking)
VI  - 11
IP  - 4
DP  - 2005
TI  - Chromosome abnormalities with prognostic impact in B-cell chronic lymphocytic 
      leukemia.
PG  - 205-10
AB  - The detailed analysis of the biologic features led to a rapid increase in 
      clinically relevant information in CLL. The recognition of the prognostic role of 
      IgVH hypermutation status and related phenotypic changes (CD38, ZAP-70 
      expression) as well as of chromosome abnormalities defined by cytogenetic 
      analysis enabled a refined classification of the disease. Improvements in 
      karyotyping and the introduction of fluorescence in situ hybridization (FISH) in 
      routine hematological diagnostics raised the detection rate of chromosomal 
      aberrations to approx. 60-80% in CLL. Among them, deletions of 17p and 11q have 
      been associated with unfavorable prognosis. The deletion of the p53 locus (17p13) 
      was described as the strongest independent predictor for aggressive behavior, 
      resistance to chemotherapy and early death. On the contrary, an isolated deletion 
      at 13q14 or a normal karyotype was related with a long survival. Classical and 
      molecular cytogenetic analysis became an important tool for individual risk 
      estimation. Unlike any other approaches, cytogenetic monitoring reflects the 
      genetic heterogeneity and clonal growth dynamics during the course of the 
      disease.
FAU - Mehes, Gabor
AU  - Mehes G
AD  - Department of Pathology, University of Pecs, Medical School, Pecs, H-7602, 
      Hungary. gabor.mehes@freemail.hu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20051231
PL  - Switzerland
TA  - Pathol Oncol Res
JT  - Pathology oncology research : POR
JID - 9706087
RN  - 0 (Immunoglobulin Variable Region)
RN  - EC 2.7.10.2 (ZAP-70 Protein-Tyrosine Kinase)
RN  - EC 2.7.10.2 (ZAP70 protein, human)
RN  - EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
SB  - IM
MH  - ADP-ribosyl Cyclase 1/genetics
MH  - *Chromosome Aberrations
MH  - *Chromosome Deletion
MH  - Cytogenetic Analysis
MH  - Gene Expression Regulation, Leukemic
MH  - Humans
MH  - Immunoglobulin Variable Region/genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*classification/*genetics/pathology
MH  - Mutation
MH  - Prognosis
MH  - ZAP-70 Protein-Tyrosine Kinase/genetics
RF  - 33
EDAT- 2006/01/03 09:00
MHDA- 2006/03/22 09:00
CRDT- 2006/01/03 09:00
PHST- 2005/10/03 00:00 [received]
PHST- 2005/11/01 00:00 [accepted]
PHST- 2006/01/03 09:00 [pubmed]
PHST- 2006/03/22 09:00 [medline]
PHST- 2006/01/03 09:00 [entrez]
AID - 10.1007/BF02893852 [doi]
PST - ppublish
SO  - Pathol Oncol Res. 2005;11(4):205-10. doi: 10.1007/BF02893852. Epub 2005 Dec 31.