PMID- 16388319
OWN - NLM
STAT- MEDLINE
DCOM- 20060321
LR  - 20191109
IS  - 1219-4956 (Print)
IS  - 1219-4956 (Linking)
VI  - 11
IP  - 4
DP  - 2005
TI  - Chromosome 1p36 and 22qter deletions in paraffin block sections of intracranial 
      meningiomas.
PG  - 224-8
AB  - Meningiomas are the most frequent benign tumors of the intracranial cavity. The 
      classification and underlying pathogenetic mechanisms have been reported to be 
      investigated by both pathological and genetic methods. In this study, we aimed to 
      detect 1p36 and 22qter deletions by fluorescence in situ hybridization (FISH) in 
      archival materials of 50 intracranial meningioma patients. The clinical material 
      consisted of paraffin-embedded tissue sections from 50 patients who were 
      surgically treated and had histopathologic diagnosis of an intracranial 
      meningioma. We observed 1p36 deletion in 23/50 (46%) and 22qter deletion in 33/50 
      (66%) patients. In addition, we observed 22qter deletion in 26/36 (72.2%) 
      patients with meningothelial meningioma. This finding implies that 22qter 
      deletion might play an important role in the pathogenesis of meningothelial 
      meningioma. On the other hand, no alterations were documented in the frequency of 
      these chromosomal alterations according to the grade of meningiomas, suggesting 
      that malignant progression of these tumors depends on other, more relevant, 
      genetic changes.
FAU - Yilmaz, Zerrin
AU  - Yilmaz Z
AD  - Department of Medical Genetics, Baskent University Faculty of Medicine, Ankara, 
      Turkey.
FAU - Sahin, Feride Iffet
AU  - Sahin FI
FAU - Atalay, Basar
AU  - Atalay B
FAU - Ozen, Ozlem
AU  - Ozen O
FAU - Caner, Hakan
AU  - Caner H
FAU - Bavbek, Murad
AU  - Bavbek M
FAU - Demirhan, Beyhan
AU  - Demirhan B
FAU - Altinors, Nur
AU  - Altinors N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051231
PL  - Switzerland
TA  - Pathol Oncol Res
JT  - Pathology oncology research : POR
JID - 9706087
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Chromosomes, Human, Pair 22/*genetics
MH  - Data Interpretation, Statistical
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Meningeal Neoplasms/*genetics
MH  - Meningioma/*genetics
MH  - Middle Aged
EDAT- 2006/01/03 09:00
MHDA- 2006/03/22 09:00
CRDT- 2006/01/03 09:00
PHST- 2005/06/29 00:00 [received]
PHST- 2005/11/22 00:00 [accepted]
PHST- 2006/01/03 09:00 [pubmed]
PHST- 2006/03/22 09:00 [medline]
PHST- 2006/01/03 09:00 [entrez]
AID - 10.1007/BF02893855 [doi]
PST - ppublish
SO  - Pathol Oncol Res. 2005;11(4):224-8. doi: 10.1007/BF02893855. Epub 2005 Dec 31.