PMID- 16389168
OWN - NLM
STAT- MEDLINE
DCOM- 20060525
LR  - 20131121
IS  - 1056-8727 (Print)
IS  - 1056-8727 (Linking)
VI  - 20
IP  - 1
DP  - 2006 Jan-Feb
TI  - Motor cortical excitability remains unaffected of short-term hyperglycemia in 
      Type 1 diabetic patients.
PG  - 51-5
AB  - BACKGROUND: In diabetic patients, hyperglycemia may precipitate seizures, and in 
      experimental diabetes, indications for an increased neuronal excitability have 
      been found. In this study, the excitability of the motor cortex and conduction of 
      the central motor pathways were studied in diabetic patients in relation to the 
      glycemic level. METHODS: Using a double-blind study protocol, transcranial 
      magnetic stimulation (TMS) was performed in five Type 1 diabetic patients during 
      normo- and hyperglycemia, using a hyperglycemic clamp technique. Single and 
      paired-pulse transcranial magnetic and single root stimulations were applied 
      before and after 3 h of a fixed glucose level of 5 and 16 mmol/l. The percentage 
      of change from baseline at the two glycemic levels was calculated and compared. 
      RESULTS: No difference in central motor conduction time was found comparing the 
      change following normo- and hyperglycemia. Furthermore, no difference was 
      observed for the changes in latency and amplitude following double stimulation 
      with interstimulation intervals (ISIs) of 0-125 ms comparing normo- and 
      hyperglycemia. CONCLUSIONS: The excitability of motor cortex and central motor 
      nerve conduction in Type 1 diabetic patients are unaffected by short-term 
      moderate hyperglycemia as compared with normoglycemia.
FAU - Andersen, Henning
AU  - Andersen H
AD  - Department of Neurology, Aarhus University Hospital Norrbrogade 44, 8000 Aarhus 
      C, Denmark. hande@as.aaa.dk
FAU - Nielsen, Soren
AU  - Nielsen S
FAU - Nielsen, Jorgen F
AU  - Nielsen JF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Type 1/blood/complications/*physiopathology
MH  - Efferent Pathways/physiology
MH  - Evoked Potentials, Motor
MH  - Female
MH  - Glucose/*administration & dosage
MH  - Humans
MH  - Hyperglycemia/etiology/*physiopathology
MH  - Hypoglycemic Agents/administration & dosage
MH  - Insulin/administration & dosage
MH  - Male
MH  - Middle Aged
MH  - Motor Cortex/*physiology
MH  - Muscle, Skeletal/*physiology
MH  - Neural Conduction/physiology
MH  - Thumb/physiology
MH  - *Transcranial Magnetic Stimulation
EDAT- 2006/01/04 09:00
MHDA- 2006/05/26 09:00
CRDT- 2006/01/04 09:00
PHST- 2005/01/12 00:00 [received]
PHST- 2005/03/30 00:00 [revised]
PHST- 2005/06/01 00:00 [accepted]
PHST- 2006/01/04 09:00 [pubmed]
PHST- 2006/05/26 09:00 [medline]
PHST- 2006/01/04 09:00 [entrez]
AID - S1056-8727(05)00054-1 [pii]
AID - 10.1016/j.jdiacomp.2005.06.001 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2006 Jan-Feb;20(1):51-5. doi: 
      10.1016/j.jdiacomp.2005.06.001.