PMID- 16389586
OWN - NLM
STAT- MEDLINE
DCOM- 20060501
LR  - 20200930
IS  - 1552-4841 (Print)
IS  - 1552-4841 (Linking)
VI  - 141B
IP  - 2
DP  - 2006 Mar 5
TI  - Characteristics of the broader phenotype in autism: a study of siblings using the 
      children's communication checklist-2.
PG  - 117-22
AB  - Non-autistic relatives of people with autistic disorder have an increased risk of 
      social and communicative difficulties: this is known as the "broad phenotype." 
      Better methods for characterizing the broad phenotype are needed to facilitate 
      identification of risk genes for autism. 29 siblings of 20 children with autistic 
      disorder, 13 siblings of 9 children with PDDNOS, and 46 typically developing 
      control children from 26 families were assessed by parental report using the 
      Children's Communication Checklist-2 (CCC-2). Groups were matched on age and IQ 
      and siblings with autism were excluded. Group mean scores on the CCC-2 differed 
      on only one subscale, syntax. However, siblings of children with autism or PDDNOS 
      were over-represented in the tails of the distributions of several scales, and 10 
      (24%) scored more than 2 SD below the control mean on a total score based on all 
      10 subscales. Only two of these 10 children scored above threshold on one or more 
      scales of the Autism Diagnostic Interview-Revised (ADI-R). Children with abnormal 
      scores on the CCC-2 total were characterized by low-verbal IQ and their fathers 
      tended to score high on the social and communication scales of the Autism 
      Quotient, a measure of the broad phenotype in adults. The CCC-2 shows promise as 
      a quick screening device for the broad phenotype in non-autistic siblings of 
      children with autism.
CI  - (c) 2006 Wiley-Liss, Inc.
FAU - Bishop, Dorothy V M
AU  - Bishop DV
AD  - Department of Experimental Psychology, Oxford University, Oxford, United Kingdom. 
      dorothy.bishop@psy.ox.ac.uk
FAU - Maybery, Murray
AU  - Maybery M
FAU - Wong, Dana
AU  - Wong D
FAU - Maley, Alana
AU  - Maley A
FAU - Hallmayer, Joachim
AU  - Hallmayer J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
SB  - IM
EIN - Am J Med Genet B Neuropsychiatr Genet. 2020 Jan;183(1):74. PMID: 31808319
MH  - Adolescent
MH  - Autistic Disorder/genetics/*psychology
MH  - Child
MH  - Humans
MH  - Phenotype
MH  - Psychiatric Status Rating Scales
MH  - Sibling Relations
MH  - Siblings/*psychology
MH  - *Surveys and Questionnaires
EDAT- 2006/01/04 09:00
MHDA- 2006/05/02 09:00
CRDT- 2006/01/04 09:00
PHST- 2006/01/04 09:00 [pubmed]
PHST- 2006/05/02 09:00 [medline]
PHST- 2006/01/04 09:00 [entrez]
AID - 10.1002/ajmg.b.30267 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2006 Mar 5;141B(2):117-22. doi: 
      10.1002/ajmg.b.30267.