PMID- 16389660
OWN - NLM
STAT- MEDLINE
DCOM- 20060706
LR  - 20131121
IS  - 0260-437X (Print)
IS  - 0260-437X (Linking)
VI  - 26
IP  - 3
DP  - 2006 May-Jun
TI  - Hematological parameters in tench Tinca tinca after short term exposure to lead.
PG  - 223-8
AB  - Alterations in the hematological parameters of Tinca tinca were studied after 
      exposure to lead at different concentrations and durations of exposure. Dose of 
      75/24 (ppm/h) did not cause significant change in any blood parameter. The 300/48 
      dose caused a significant increase in hematocrit (Hct), mean corpuscular volume 
      (MCV) and mean corpuscular hemoglobin (MCH) and a significant decrease in red 
      blood cell (RBC) count and mean corpuscular hemoglobin concentration (MCHC). The 
      30/24 dose caused a significant increase in Hct and RBC count only. The 30/96 
      dose caused a significant increase in Hct and a significant decrease in MCHC 
      only. The 30/504 dose caused a significant decrease in RBC count and a 
      significant increase in MCV and MCH. The 75/96 dose caused a significant increase 
      in Hct and a significant decrease in MCH and MCHC. The 75/504 dose caused a 
      significant decrease in Hct, hemoglobin (Hb) and RBC count, and a significant 
      increase in MCV and MCH. These alterations were attributed to direct or feedback 
      responses of structural damage to RBC membranes resulting in hemolysis and 
      impairment in hemoglobin synthesis, stress related release of RBCs from the 
      spleen and hypoxia, induced by exposure to lead.
CI  - Copyright 2006 John Wiley & Sons, Ltd.
FAU - Shah, Syed Lal
AU  - Shah SL
AD  - Pakistan Science Foundation, Islamabad. drsyed_1@yahoo.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Appl Toxicol
JT  - Journal of applied toxicology : JAT
JID - 8109495
RN  - 0 (Hemoglobins)
RN  - 0 (Nitrates)
RN  - 0 (Water Pollutants, Chemical)
RN  - 2P299V784P (Lead)
RN  - 6E5P1699FI (lead nitrate)
SB  - IM
MH  - Animals
MH  - Cyprinidae/*blood
MH  - Dose-Response Relationship, Drug
MH  - Erythrocyte Count
MH  - Erythrocyte Indices
MH  - Erythrocytes/cytology/*drug effects
MH  - Hematocrit
MH  - Hemoglobins/analysis
MH  - Lead/*toxicity
MH  - Lethal Dose 50
MH  - Nitrates/*toxicity
MH  - Time Factors
MH  - Water Pollutants, Chemical/*toxicity
EDAT- 2006/01/04 09:00
MHDA- 2006/07/11 09:00
CRDT- 2006/01/04 09:00
PHST- 2006/01/04 09:00 [pubmed]
PHST- 2006/07/11 09:00 [medline]
PHST- 2006/01/04 09:00 [entrez]
AID - 10.1002/jat.1129 [doi]
PST - ppublish
SO  - J Appl Toxicol. 2006 May-Jun;26(3):223-8. doi: 10.1002/jat.1129.