PMID- 16390390
OWN - NLM
STAT- MEDLINE
DCOM- 20060307
LR  - 20221207
IS  - 1399-543X (Print)
IS  - 1399-543X (Linking)
VI  - 6
IP  - 4
DP  - 2005 Dec
TI  - Genetic interaction among three genomic regions creates distinct contributions to 
      early- and late-onset type 1 diabetes mellitus.
PG  - 213-20
AB  - There are two peaks in the distribution of the age of onset of type 1 diabetes 
      mellitus (T1DM)--the first in early childhood and the second at the time of 
      puberty. Although T1DM results from the interaction of genetic and non-genetic 
      factors, it has not been established which factors contribute to the bimodal 
      distribution. The genetic component of T1DM is in large part related to genes 
      from the human leukocyte antigen (HLA) complex (IDDM1); however, loci from the 
      variable nucleotide tandem repeat (VNTR) region of the insulin (INS) gene (IDDM2) 
      and more recently, the cytotoxic T-lymphocyte-associated protein-4 region (CTLA4, 
      IDDM12) have also been implicated. Therefore, we examined the potential 
      interaction between these loci through the influence of the age of onset of T1DM 
      in diabetic and control Caucasian individuals. We discovered that younger 
      individuals with HLA-DRB1*0301/DRB1*04 and INS I/I genotypes exhibited increased 
      susceptibility to T1DM, whereas the interaction of INS I/I and CTLA4 G/G 
      genotypes was more common in older children with T1DM. Combining the age of onset 
      of T1DM with specific genotypes may operate to produce a single disease through 
      different underlying causes.
FAU - Felner, Eric I
AU  - Felner EI
AD  - Department of Pediatrics, Division of Endocrinology, University of Texas 
      Southwestern Medical Center, Dallas, TX, USA. eric_felner@oz.ped.emory.edu
FAU - Klitz, William
AU  - Klitz W
FAU - Ham, Melissa
AU  - Ham M
FAU - Lazaro, Ana M
AU  - Lazaro AM
FAU - Stastny, Peter
AU  - Stastny P
FAU - Dupont, Bo
AU  - Dupont B
FAU - White, Perrin C
AU  - White PC
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
SB  - IM
MH  - Adolescent
MH  - Age Distribution
MH  - Age of Onset
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/epidemiology/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - White People
EDAT- 2006/01/05 09:00
MHDA- 2006/03/08 09:00
CRDT- 2006/01/05 09:00
PHST- 2006/01/05 09:00 [pubmed]
PHST- 2006/03/08 09:00 [medline]
PHST- 2006/01/05 09:00 [entrez]
AID - PDI132 [pii]
AID - 10.1111/j.1399-543X.2005.00132.x [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2005 Dec;6(4):213-20. doi: 10.1111/j.1399-543X.2005.00132.x.