PMID- 16390786
OWN - NLM
STAT- MEDLINE
DCOM- 20060504
LR  - 20061115
IS  - 1476-7058 (Print)
IS  - 1476-4954 (Linking)
VI  - 18
IP  - 5
DP  - 2005 Nov
TI  - TNF-receptor levels in preeclampsia--results of a longitudinal study in high-risk 
      women.
PG  - 283-7
AB  - OBJECTIVE: Tumor necrosis factor-alpha (TNF-alpha) is thought to play a role in 
      immune activation in preeclampsia. The objective of this study was to establish 
      if soluble TNF-receptor I (sTNF-rI) levels relate to the onset and severity of 
      preeclampsia. METHODS: Maternal plasma sTNF-rI levels were studied throughout 
      pregnancy in 68 women with a history of severe preeclampsia or intra-uterine 
      growth restriction (IUGR), and primigravidas with chronic hypertension. Data are 
      presented as mean (SD) in ng/ml. RESULTS: In the second trimester there was a 
      significant difference in sTNF-rI levels between preeclamptic pregnancies with 
      and without IUGR (means 1.33 (0.20) and 1.11 (0.15) respectively, p < 0.005). In 
      severe preeclampsia with delivery before 34 weeks of gestation, sTNF-rI levels 
      were higher than in mild preeclampsia in the second and third trimesters (means 
      1.40 (0.16) vs. 1.16 (0.19), p < 0.02 and 1.82 (0.47) vs. 1.42 (0.22), p < 0.05, 
      respectively). CONCLUSION: sTNF-rI levels were higher in preeclampsia with fetal 
      involvement, suggesting that increased TNF-alpha production in preeclampsia is 
      related to impaired placentation rather than to the maternal syndrome.
FAU - Schipper, Elbert-Jaap I
AU  - Schipper EJ
AD  - Department of Obstetrics and Gynecology, Vrije Universiteit Medical Center, 
      Amsterdam, the Netherlands.
FAU - Bolte, Antoinette C
AU  - Bolte AC
FAU - Schalkwijk, Casper G
AU  - Schalkwijk CG
FAU - Van Geijn, Herman P
AU  - Van Geijn HP
FAU - Dekker, Gustaaf A
AU  - Dekker GA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the 
      European Association of Perinatal Medicine, the Federation of Asia and Oceania 
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
SB  - IM
MH  - Adult
MH  - Female
MH  - Fetal Growth Retardation/blood
MH  - Gestational Age
MH  - Humans
MH  - Longitudinal Studies
MH  - Pre-Eclampsia/*blood
MH  - Pregnancy
MH  - Receptors, Tumor Necrosis Factor, Type I/*blood
MH  - Risk Factors
MH  - Severity of Illness Index
EDAT- 2006/01/05 09:00
MHDA- 2006/05/05 09:00
CRDT- 2006/01/05 09:00
PHST- 2006/01/05 09:00 [pubmed]
PHST- 2006/05/05 09:00 [medline]
PHST- 2006/01/05 09:00 [entrez]
AID - RT7W5Q801U3V4826 [pii]
AID - 10.1080/14767050500246466 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2005 Nov;18(5):283-7. doi: 
      10.1080/14767050500246466.