PMID- 16391394 OWN - NLM STAT- MEDLINE DCOM- 20060329 LR - 20191109 IS - 1080-0549 (Print) IS - 1080-0549 (Linking) VI - 29 IP - 3 DP - 2005 Dec TI - Intravenous immunoglobulin and dendritic cells. PG - 201-5 AB - Intravenous immunoglobulin (IVIg) has increasingly been used for the treatment of autoimmune and systemic inflammatory diseases, and in supportive therapy of immunodeficient patients. Available clinical and experimental evidence suggests, however, that a wide spectrum of immune-mediated conditions could benefit from IVIg, including acute and chronic/relapsing diseases and autoimmune diseases mediated by pathogenic autoantibodies or by autoaggressive T-cells. Dendritic cells (DCs) are professional antigen-presenting cells and because of their capacity to stimulate naive T-cells, they play a central role in the initiation of primary immune responses. Several immunomodulatory agents have been shown to inhibit DC activation. Recently, we examined the effects of IVIg on differentiation, maturation, and functions of DCs. We demonstrate that DCs are one of the targets for the immunomodulatory effects of IVIg. FAU - Misra, Namita AU - Misra N AD - Inserm, U681, Paris, France. FAU - Bayry, Jagadeesh AU - Bayry J FAU - Dasgupta, Sooryasarathi AU - Dasgupta S FAU - Ephrem, Amal AU - Ephrem A FAU - Huyen, Jean-Paul Duong Van AU - Huyen JP FAU - Delignat, Sandrine AU - Delignat S FAU - Hassan, Gazzala AU - Hassan G FAU - Caligiuri, Giuseppina AU - Caligiuri G FAU - Nicoletti, Antonino AU - Nicoletti A FAU - Lacroix-Desmazes, Sebastien AU - Lacroix-Desmazes S FAU - Kazatchkine, Michel D AU - Kazatchkine MD FAU - Kaveri, Srini V AU - Kaveri SV LA - eng PT - Journal Article PT - Review PL - United States TA - Clin Rev Allergy Immunol JT - Clinical reviews in allergy & immunology JID - 9504368 RN - 0 (Immunoglobulins, Intravenous) SB - IM EIN - Clin Rev Allergy Immunol. 2015 Oct;49(2):262. Bayary, Jagadeesh [corrected to Bayry, Jagadeesh] MH - Animals MH - Antigen Presentation/drug effects/immunology MH - Cell Differentiation MH - Dendritic Cells/cytology/*drug effects/*immunology MH - Humans MH - Immunoglobulins, Intravenous/*immunology/*pharmacology RF - 32 EDAT- 2006/01/05 09:00 MHDA- 2006/03/30 09:00 CRDT- 2006/01/05 09:00 PHST- 2006/01/05 09:00 [pubmed] PHST- 2006/03/30 09:00 [medline] PHST- 2006/01/05 09:00 [entrez] AID - CRIAI:29:3:201 [pii] AID - 10.1385/criai:29:3:201 [doi] PST - ppublish SO - Clin Rev Allergy Immunol. 2005 Dec;29(3):201-5. doi: 10.1385/criai:29:3:201.