PMID- 16391465
OWN - NLM
STAT- MEDLINE
DCOM- 20060811
LR  - 20220318
IS  - 0250-8095 (Print)
IS  - 0250-8095 (Linking)
VI  - 26
IP  - 1
DP  - 2006
TI  - Tumor necrosis factor-alpha gene G-308A polymorphism is a risk factor for the 
      development of membranous glomerulonephritis.
PG  - 12-5
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is a major pro-inflammatory 
      cytokine. Recently, the G-308A polymorphism of the TNF-alpha gene has been 
      associated with modified gene expression and increased TNF-alpha production in 
      the -308A allele. We evaluated its influence on the incidence and clinical course 
      of membranous glomerulonephritis. METHODS: We studied 53 patients with 
      biopsy-proven primary membranous glomerulonephritis followed up for 5.7 +/- 4.9 
      years. 100 volunteers were analyzed as controls. According to the slope of the 
      curve of reciprocal serum creatinine against time, group A (slow progressors, n = 
      35) and group B (fast progressors, n = 18) were defined. TNF-alpha G-308A 
      polymorphism was determined by polymerase chain reaction amplification. RESULTS: 
      The frequency of the A-allele (associated with higher TNF-alpha levels) was 
      significantly higher in patients than control subjects (patients: G-allele: 0.66, 
      A-allele: 0.34; controls: G-allele 0.85, A-allele 0.15, p < 0.001). Similarly, 
      the genotype distribution differed significantly between our study and control 
      populations (patients: GG-genotype: 41.5%, GA: 49.1%, AA 9.4%; controls: GG: 71%, 
      GA: 27%, AA 2%, p = 0.001). Age, renal function, proteinuria and blood pressure 
      were similar at the time of renal biopsy between patients with different 
      genotypes (NS). There was also a tendency towards an overpresentation of the 
      A-allele in group B indicating a possible impact on the progression of membranous 
      nephropathy, but a significance was not reached. Furthermore, no impact on renal 
      survival in the Kaplan- Meier analysis was detected (NS). CONCLUSION: Our results 
      suggest that TNF-alpha gene G-308A polymorphism is a risk factor for the 
      development of membranous glomerulonephritis.
CI  - Copyright 2006 S. Karger AG, Basel
FAU - Bantis, Christos
AU  - Bantis C
AD  - Department of Nephrology, Heinrich Heine University, Dusseldorf, Germany.
FAU - Heering, Peter J
AU  - Heering PJ
FAU - Aker, Sendogan
AU  - Aker S
FAU - Siekierka, Magdalena
AU  - Siekierka M
FAU - Kuhr, Nicola
AU  - Kuhr N
FAU - Grabensee, Bernd
AU  - Grabensee B
FAU - Ivens, Katrin
AU  - Ivens K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060102
PL  - Switzerland
TA  - Am J Nephrol
JT  - American journal of nephrology
JID - 8109361
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Female
MH  - Glomerulonephritis, Membranous/*genetics
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2006/01/05 09:00
MHDA- 2006/08/12 09:00
CRDT- 2006/01/05 09:00
PHST- 2005/11/22 00:00 [received]
PHST- 2005/11/29 00:00 [accepted]
PHST- 2006/01/05 09:00 [pubmed]
PHST- 2006/08/12 09:00 [medline]
PHST- 2006/01/05 09:00 [entrez]
AID - 90706 [pii]
AID - 10.1159/000090706 [doi]
PST - ppublish
SO  - Am J Nephrol. 2006;26(1):12-5. doi: 10.1159/000090706. Epub 2006 Jan 2.