PMID- 16393763
OWN - NLM
STAT- MEDLINE
DCOM- 20060328
LR  - 20151119
IS  - 0300-9742 (Print)
IS  - 0300-9742 (Linking)
VI  - 34
IP  - 6
DP  - 2005 Nov-Dec
TI  - Is interleukin-18 useful for monitoring rheumatoid arthritis?
PG  - 433-6
AB  - OBJECTIVE: Interleukin-18 (IL-18) is a proinflammatory regulator of immune 
      responses. Its similarities to IL-1beta and ability to induce tumour necrosis 
      factor-alpha (TNF-alpha) make it potentially important in the pathogenesis of 
      rheumatoid arthritis (RA). METHODS: The level of IL-18 was assessed in matched 
      pairs of blood and synovial fluid samples from 90 RA patients (47 erosive, 43 
      non-erosive) by an enzyme-linked immunosorbent assay (ELISA), and the results 
      compared to 40 healthy controls. RESULTS: In RA patients with erosive joint 
      disease, the IL-18 level was higher than that in non-erosive RA [(median+/-QR) 
      blood: 385+/-200 vs. 235+/-183 pg/mL, p = 0.02; synovial fluid: 392+/-392 vs. 
      224+/-324 pg/mL, p = 0.05]. IL-18 levels in blood of RA patients were similar and 
      closely related to the local, intra-articular level (r = 0.96). The IL-18 level 
      was not related to other markers of inflammation, to the duration of RA, or to 
      the treatment modality. The IL-18 level in RA patients was similar to that of the 
      controls (278+/-234 vs. 344+/-179 pg/mL, not significant). CONCLUSIONS: An 
      increased IL-18 level is associated with erosive joint disease, but the 
      measurement of IL-18 does not help to distinguish between RA patients and healthy 
      controls.
FAU - Bokarewa, M
AU  - Bokarewa M
AD  - Department of Rheumatology, Goteborg University, Sweden. 
      maria.bokarewa@rheuma.gu.se
FAU - Hultgren, O
AU  - Hultgren O
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Rheumatol
JT  - Scandinavian journal of rheumatology
JID - 0321213
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Arthritis, Rheumatoid/*blood
MH  - Biomarkers/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Interleukin-18/*blood
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Immunologic/methods
MH  - Synovial Fluid/*metabolism
EDAT- 2006/01/06 09:00
MHDA- 2006/03/29 09:00
CRDT- 2006/01/06 09:00
PHST- 2006/01/06 09:00 [pubmed]
PHST- 2006/03/29 09:00 [medline]
PHST- 2006/01/06 09:00 [entrez]
AID - W084029L1035267M [pii]
AID - 10.1080/03009740510026724 [doi]
PST - ppublish
SO  - Scand J Rheumatol. 2005 Nov-Dec;34(6):433-6. doi: 10.1080/03009740510026724.