PMID- 16394591
OWN - NLM
STAT- MEDLINE
DCOM- 20060224
LR  - 20191109
IS  - 1349-2365 (Print)
IS  - 1349-2365 (Linking)
VI  - 46
IP  - 6
DP  - 2005 Nov
TI  - Influence of primary coronary intervention on myocardial collagen metabolism and 
      left ventricle remodeling predicted by collagen metabolism markers.
PG  - 949-59
AB  - The aims of the present study were to analyze cardiac collagen metabolism changes 
      in vivo during acute and nonacute phases of ST elevation myocardial infarction 
      (STEMI) in patients who were treated with primary coronary intervention (PCI) 
      only, and to determine the predictive significance of collagen I and III 
      synthesis markers (PICP, PIIINP) as well as the collagen I degradation marker 
      (ICTP) on left ventricular function and volume changes after STEMI. Serum levels 
      of the carboxy-terminal propeptide of type I procollagen (PICP) and 
      amino-terminal propeptide of type III procollagen (PIIINP) assessed on the 30th 
      day and the carboxyterminal telopeptide located at the C end of collagen type I 
      (ICTP) assessed on the 7th day after STEMI were significantly higher (P = 0.01, P 
      = 0.019, P = 0.04, respectively) in the PCI unsuccessful group than in the PCI 
      successful group. These findings support the theory that early and successful PCI 
      not only limits the amount of muscle necrosis but also protects cardiac collagen 
      from ischemia-related injury. PICP and PIIINP levels assessed on the fourth day 
      after acute STEMI enables us to predict the development of left ventricular 
      function (EF) and end-diastolic volume changes over the course of 6 months, 
      irrespective of the initial EF or revascularization success.
FAU - Jirmar, Radovan
AU  - Jirmar R
AD  - Cardiocenter, Department of Cardiology, 3rd Medical School, Charles University 
      and University Hospital, Kralovske Vinohrady, Czech Repiblic.
FAU - Pelouch, Vaclav
AU  - Pelouch V
FAU - Widimsky, Petr
AU  - Widimsky P
FAU - Capek, Jan
AU  - Capek J
FAU - Andel, Michal
AU  - Andel M
FAU - Prusa, Richard
AU  - Prusa R
FAU - Pechova, Martina
AU  - Pechova M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Int Heart J
JT  - International heart journal
JID - 101244240
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (Procollagen)
RN  - 0 (procollagen Type III-N-terminal peptide)
RN  - 0 (procollagen type I carboxy terminal peptide)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Aged
MH  - *Angioplasty, Balloon, Coronary
MH  - Biomarkers/metabolism
MH  - Collagen/*metabolism
MH  - Electrocardiography
MH  - Extracellular Matrix/metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/metabolism/*physiopathology/therapy
MH  - Myocardium/*metabolism
MH  - Peptide Fragments/metabolism
MH  - Procollagen/metabolism
MH  - Ventricular Function, Left
MH  - *Ventricular Remodeling
EDAT- 2006/01/06 09:00
MHDA- 2006/02/25 09:00
CRDT- 2006/01/06 09:00
PHST- 2006/01/06 09:00 [pubmed]
PHST- 2006/02/25 09:00 [medline]
PHST- 2006/01/06 09:00 [entrez]
AID - JST.JSTAGE/ihj/46.949 [pii]
AID - 10.1536/ihj.46.949 [doi]
PST - ppublish
SO  - Int Heart J. 2005 Nov;46(6):949-59. doi: 10.1536/ihj.46.949.