PMID- 16394843
OWN - NLM
STAT- MEDLINE
DCOM- 20060331
LR  - 20200930
IS  - 1525-4135 (Print)
IS  - 1525-4135 (Linking)
VI  - 41
IP  - 2
DP  - 2006 Feb 1
TI  - Accelerating effect of human leukocyte antigen-Bw6 homozygosity on disease 
      progression in Chinese HIV-1-infected patients.
PG  - 137-9
AB  - Most HIV-1-infected individuals progress to AIDS within 8 to 10 years after 
      seroconversion. Less than 5% of them, however, remain asymptomatic, although 
      their CD4 T-cell counts stay normal. In this study, our polymerase chain reaction 
      sequence-specified primer (PCR-SSP) based human leukocyte antigen (HLA)-B 
      genotyping of 28 typical progressors (TPs) and 15 long-term nonprogressors 
      (LTNPs) revealed some evidence that an HLA-B locus polymorphism can influence the 
      rate of disease progression in Chinese HIV-1-infected individuals: 12 of 28 TPs 
      (43%) were HLA-Bw6 homozygotes. Only 1 of 15 LTNPs (6.7%) was homozygous for the 
      polymorphism (P = 0.013), suggesting that HLA-Bw6 homozygosity is associated with 
      accelerated disease progression. In contrast, 3 of 15 LTNPs (20%) were HLA-Bw4 
      homozygotes, whereas none of the 28 TPs were homozygotes (P = 0.037), supporting 
      the conclusion that HLA-Bw4 homozygosity may have a protective role. 
      Interestingly, the frequency of the HLA-B*15 allele was extremely high in the TP 
      group (23.2%), which may be associated with faster disease progression in Chinese 
      patients.
FAU - Qing, Manli
AU  - Qing M
AD  - Department of Infectious Disease, Peking Union Medical College Hospital, Beijing, 
      100730, China.
FAU - Li, Taisheng
AU  - Li T
FAU - Han, Yang
AU  - Han Y
FAU - Qiu, Zhifeng
AU  - Qiu Z
FAU - Jiao, Yang
AU  - Jiao Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-Bw4 antigen)
RN  - 0 (HLA-Bw6 antigen)
SB  - IM
MH  - Adult
MH  - China
MH  - Disease Progression
MH  - Female
MH  - HIV Infections/diagnosis/*genetics
MH  - *HIV-1
MH  - HLA-B Antigens/*genetics
MH  - *Homozygote
MH  - Humans
MH  - Male
EDAT- 2006/01/06 09:00
MHDA- 2006/04/01 09:00
CRDT- 2006/01/06 09:00
PHST- 2006/01/06 09:00 [pubmed]
PHST- 2006/04/01 09:00 [medline]
PHST- 2006/01/06 09:00 [entrez]
AID - 00126334-200602010-00002 [pii]
AID - 10.1097/01.qai.0000195607.25262.92 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2006 Feb 1;41(2):137-9. doi: 
      10.1097/01.qai.0000195607.25262.92.