PMID- 16395141
OWN - NLM
STAT- MEDLINE
DCOM- 20060307
LR  - 20190907
IS  - 0275-004X (Print)
IS  - 0275-004X (Linking)
VI  - 26
IP  - 1
DP  - 2006 Jan
TI  - Moderate hyperhomocysteinemia and early-onset central retinal vein occlusion.
PG  - 65-70
AB  - PURPOSE: To evaluate the prevalence of moderate fasting hyperhomocysteinemia 
      (HHcy) and postmethionine load (PML) HHcy among patients with early-onset central 
      retinal vein occlusion (CRVO). METHODS: The prevalence of fasting HHcy and that 
      of PML HHcy were evaluated in a consecutive series of 58 patients with CRVO who 
      were younger than 56 years of age (mean age, 40.3 years) and in 103 controls 
      (mean age, 39.6 years). Plasma folate, vitamin B12, and pyridoxal-5'-phosphate 
      (PLP) levels were measured in 42 patients and 67 controls. RESULTS: 
      Mantel-Haenszel odds ratios for CRVO patients were 3.00 (95% confidence interval 
      [CI], 0.83-10.8) for fasting HHcy, 3.50 (95% CI, 1.07-11.4) for PML HHcy, and 
      3.00 (1.18-7.6) for fasting HHcy and PML HHcy in subjects with normal fasting 
      total homocysteine (tHcy) levels. Moderate HHcy was associated with reduced 
      plasma levels of folate and PLP (P < or = 0.04). There was no significant 
      dependence of fasting and PML tHcy levels on any traditional risk factor 
      evaluated. CONCLUSIONS: Moderate HHcy is an independent risk factor for 
      early-onset CRVO.
FAU - Lattanzio, Rosangela
AU  - Lattanzio R
AD  - Department of Ophthalmology & Visual Sciences, University Hospital S. Raffaele, 
      Milan, Italy. lattanzio.rosangela@hsr.it
FAU - Sampietro, Francesca
AU  - Sampietro F
FAU - Ramoni, Andrea
AU  - Ramoni A
FAU - Fattorini, Annalisa
AU  - Fattorini A
FAU - Brancato, Rosario
AU  - Brancato R
FAU - D'Angelo, Armando
AU  - D'Angelo A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Retina
JT  - Retina (Philadelphia, Pa.)
JID - 8309919
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 5V5IOJ8338 (Pyridoxal Phosphate)
RN  - 935E97BOY8 (Folic Acid)
RN  - AE28F7PNPL (Methionine)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chromatography, High Pressure Liquid
MH  - Fasting/blood
MH  - Female
MH  - Folic Acid/blood
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/*complications
MH  - Male
MH  - Methionine/administration & dosage
MH  - Middle Aged
MH  - Pyridoxal Phosphate/blood
MH  - Retinal Vein Occlusion/blood/*etiology
MH  - Risk Factors
MH  - Vitamin B 12/blood
EDAT- 2006/01/06 09:00
MHDA- 2006/03/08 09:00
CRDT- 2006/01/06 09:00
PHST- 2006/01/06 09:00 [pubmed]
PHST- 2006/03/08 09:00 [medline]
PHST- 2006/01/06 09:00 [entrez]
AID - 00006982-200601000-00011 [pii]
AID - 10.1097/00006982-200601000-00011 [doi]
PST - ppublish
SO  - Retina. 2006 Jan;26(1):65-70. doi: 10.1097/00006982-200601000-00011.