PMID- 16396853
OWN - NLM
STAT- MEDLINE
DCOM- 20060207
LR  - 20161124
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 117
IP  - 1
DP  - 2006 Jan
TI  - Hemodynamics of the cerebral arteries of infants with periventricular 
      leukomalacia.
PG  - 1-8
AB  - OBJECTIVE: This study investigated the developmental changes in blood flow in 
      each cerebral artery among infants with and without periventricular leukomalacia 
      (PVL), to elucidate the time of onset of PVL. METHODS: Eight of 67 low birth 
      weight infants were diagnosed through ultrasonography as having PVL with cyst 
      formation. The mean cerebral blood flow velocities (CBFVs) in the anterior 
      cerebral artery, middle cerebral arteries (MCAs), posterior cerebral arteries 
      (PCAs), internal carotid arteries (ICAs), and basilar artery were measured with 
      Doppler ultrasonography at postnatal days 0, 1, 2, 3, 4, 5, 7, 10, 14, 21, 28, 
      42, 56, and 70. Four of 8 infants with cyst formation and 1 of 59 infants without 
      cyst formation developed cerebral palsy. RESULTS: The mean CBFVs of infants with 
      PVL were significantly lower in the anterior cerebral artery (days 14-70), the 
      right MCA (days 14-70), the left MCA (days 14-70), the right PCA (days 7-70), the 
      left PCA (days 5-70), the right ICA (days 7-70), the left ICA (days 7-70), and 
      the basilar artery (days 14 and 28-70). The CBFVs in all arteries were also lower 
      among those with PVL than among intact infants on day 0. The CBFVs increased 
      postnatally in the PCAs of infants with intact brains, whereas they remained 
      unchanged after day 14 or 21 among infants with PVL. There was a significant 
      difference in the prevalence of cerebral palsy between the 2 groups. CONCLUSIONS: 
      We suggest that the total cerebral blood supply is decreased in cases of cystic 
      PVL and that this reduction occurs just after birth, in a defined sequence, in 
      the cerebral arteries. We conclude that the insult resulting in PVL might occur 
      close to the time of birth.
FAU - Fukuda, Sumio
AU  - Fukuda S
AD  - Department of Pediatrics, Neonatology, and Congenital Disorders, Nagoya City 
      University, Graduate School of Medical Sciences, Nagoya, Japan. 
      fukuda@med.nagoya-cu.ac.jp
FAU - Kato, Takenori
AU  - Kato T
FAU - Kakita, Hiroki
AU  - Kakita H
FAU - Yamada, Yasumasa
AU  - Yamada Y
FAU - Hussein, Mohamed Hamed
AU  - Hussein MH
FAU - Kato, Ineko
AU  - Kato I
FAU - Suzuki, Satoshi
AU  - Suzuki S
FAU - Togari, Hajime
AU  - Togari H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
CIN - Pediatrics. 2006 Jan;117(1):212-3. PMID: 16396880
MH  - *Blood Flow Velocity
MH  - *Cerebral Arteries/diagnostic imaging
MH  - *Cerebrovascular Circulation
MH  - Hemodynamics
MH  - Humans
MH  - Infant
MH  - Infant, Low Birth Weight
MH  - Infant, Newborn
MH  - Leukomalacia, Periventricular/diagnosis/diagnostic imaging/*physiopathology
MH  - Ultrasonography, Doppler, Transcranial
EDAT- 2006/01/07 09:00
MHDA- 2006/02/08 09:00
CRDT- 2006/01/07 09:00
PHST- 2006/01/07 09:00 [pubmed]
PHST- 2006/02/08 09:00 [medline]
PHST- 2006/01/07 09:00 [entrez]
AID - 117/1/1 [pii]
AID - 10.1542/peds.2004-1719 [doi]
PST - ppublish
SO  - Pediatrics. 2006 Jan;117(1):1-8. doi: 10.1542/peds.2004-1719.