PMID- 1639743
OWN - NLM
STAT- MEDLINE
DCOM- 19920828
LR  - 20131121
IS  - 0160-6689 (Print)
IS  - 0160-6689 (Linking)
VI  - 53
IP  - 7
DP  - 1992 Jul
TI  - Clozapine-induced agranulocytosis in a Native American: HLA typing and further 
      support for an immune-mediated mechanism.
PG  - 242-4
AB  - BACKGROUND: Approximately 30% of schizophrenic patients defined as treatment 
      refractory significantly improve with clozapine. However, clozapine produces 
      agranulocytosis in approximately 1% to 2% of patients in the United States. The 
      mechanism of clozapine-induced agranulocytosis has not been established, but 
      evidence suggests an immune-mediated mechanism. METHOD: Human leukocyte antigen 
      (HLA) typing was performed in a native American with clozapine-induced 
      agranulocytosis. RESULTS: Our findings support previous observations of a role of 
      the HLA-B16, DR4, DQw3 haplotype in predicting susceptibility to agranulocytosis 
      in clozapine-treated patients. CONCLUSION: We suggest that HLA typing of 
      clozapine candidates may be useful for predicting the risk for clozapine-induced 
      agranulocytosis.
FAU - Pfister, G M
AU  - Pfister GM
AD  - St. Paul Ramsey Medical Center, Department of Psychiatry, MN 55101-2595.
FAU - Hanson, D R
AU  - Hanson DR
FAU - Roerig, J L
AU  - Roerig JL
FAU - Landbloom, R
AU  - Landbloom R
FAU - Popkin, M K
AU  - Popkin MK
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Clin Psychiatry
JT  - The Journal of clinical psychiatry
JID - 7801243
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B16 antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ3 antigen)
RN  - 0 (HLA-DR4 Antigen)
RN  - J60AR2IKIC (Clozapine)
SB  - IM
CIN - J Clin Psychiatry. 1993 Jun;54(6):236-7. PMID: 8331095
MH  - Adult
MH  - Agranulocytosis/*chemically induced/immunology
MH  - Clozapine/*adverse effects/immunology
MH  - HLA Antigens/genetics/*immunology
MH  - HLA-B Antigens/immunology
MH  - HLA-DQ Antigens/immunology
MH  - HLA-DR4 Antigen/immunology
MH  - Haplotypes/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Indians, North American/*genetics
MH  - Male
MH  - Risk Factors
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
PST - ppublish
SO  - J Clin Psychiatry. 1992 Jul;53(7):242-4.