PMID- 16397847
OWN - NLM
STAT- MEDLINE
DCOM- 20060920
LR  - 20131121
IS  - 0951-418X (Print)
IS  - 0951-418X (Linking)
VI  - 20
IP  - 1
DP  - 2006 Jan
TI  - Effects of Nigella orientalis and N. segetalis fixed oils on blood biochemistry 
      in rats.
PG  - 71-5
AB  - Nigella orientalis and N. segetalis fixed oils were administered orally (1 
      mL/kg/day) to Wistar Kyoto rats for 4 weeks. The effects of the oils on 
      biochemical parameters were compared with a control group that received distilled 
      water under identical conditions. LDL-cholesterol level was decreased 
      significantly in both oil groups while serum total cholesterol and 
      VLDL-cholesterol were decreased significantly following administration of only N. 
      orientalis fixed oil when compared with the control group. The HDL-cholesterol 
      levels were increased significantly in both oil groups.N. orientalis fixed oil 
      significantly reduced Aspartateaminotransferase (AST), Alkaline Phosphatase 
      (ALP), bilirubin and urea levels in rats. There was an increase in the albumin, 
      uric acid and mean corpuscular volume (MCV) concentrations, while the mean 
      corpuscular hemoglobin concentration (MCHC) and RDW (red cell distribution width) 
      levels decreased significantly. In N. segetalis fixed oil treated rats, the 
      levels of ALP, Blood Urea Nitrogen (BUN), MCHC, RDW were decreased significantly, 
      whereas a significant increase was found in albumin, fibrinogen, Hematocrit (HCT) 
      and MCV levels. The effects of 4 weeks oral intake of N. orientalis and N. 
      segetalis fixed oils on blood malondialdehyde (MDA) and total antioxidant status 
      (TOS) were also investigated in rats. The study showed that the oils had no 
      significant effect on MDA production. N. orientalis and N. segetalis fixed oils 
      caused a significant increase in the total antioxidant status in rats.
CI  - Copyright 2006 John Wiley & Sons, Ltd.
FAU - Kokdil, G
AU  - Kokdil G
AD  - Department of Pharmacognosy, Faculty of Pharmacy, Mersin University, Yenisehir 
      Campus, 33169 Mersin, Turkey. gkokdil@mersin.edu.tr
FAU - Tamer, L
AU  - Tamer L
FAU - Ercan, B
AU  - Ercan B
FAU - Celik, M
AU  - Celik M
FAU - Atik, U
AU  - Atik U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Antioxidants)
RN  - 0 (Enzymes)
RN  - 0 (Lipids)
RN  - 0 (Plant Extracts)
RN  - 0 (Plant Oils)
RN  - 0 (Serum Albumin)
RN  - 268B43MJ25 (Uric Acid)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 8W8T17847W (Urea)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Animals
MH  - Antioxidants/analysis
MH  - Bilirubin/blood
MH  - Blood Chemical Analysis
MH  - Blood Urea Nitrogen
MH  - Enzymes/blood
MH  - Hematologic Tests
MH  - Lipids/blood
MH  - Liver/enzymology
MH  - Malondialdehyde/blood
MH  - Nigella/*chemistry
MH  - Plant Extracts/chemistry/*pharmacology
MH  - Plant Oils/chemistry/isolation & purification/*pharmacology
MH  - Plants, Medicinal/chemistry
MH  - Random Allocation
MH  - Rats
MH  - Rats, Inbred WKY
MH  - Serum Albumin/analysis
MH  - Urea/blood
MH  - Uric Acid/blood
EDAT- 2006/01/07 09:00
MHDA- 2006/09/21 09:00
CRDT- 2006/01/07 09:00
PHST- 2006/01/07 09:00 [pubmed]
PHST- 2006/09/21 09:00 [medline]
PHST- 2006/01/07 09:00 [entrez]
AID - 10.1002/ptr.1809 [doi]
PST - ppublish
SO  - Phytother Res. 2006 Jan;20(1):71-5. doi: 10.1002/ptr.1809.