PMID- 16398049
OWN - NLM
STAT- MEDLINE
DCOM- 20110405
LR  - 20140625
VI  - 19
IP  - 20
DP  - 2005 Oct
TI  - [Expression of BAG-1 and p53 in laryngeal squamous cell carcinoma and their 
      clinical significance].
PG  - 932-5
AB  - OBJECTIVE: To study the expression of BAG-1 and p53 in laryngeal squamous cell 
      carcinoma (LSCC), and the relation between BAG-1 and p53. METHOD: BAG-1 and p53 
      protein were examined by using the method of immunohistochemical SP staining 
      method in 40 cases of LSCC, 27 cases of pap- a-cancerous tissues and 20 cases of 
      polyp specimens from vocal cord tissues. RESULT: The positive expression of BAG-1 
      in. LSCC was significantly higher than that in para-cancerous tissues and polyp 
      specimens from vocal cord tissues (P < 0.05). The positive expressions of BAG-1 
      were related to the prognosis (P < 0.05), and BAG-1 in LSCC with nucleus staining 
      had worse prognosis than that with cytoplasm staining (P < 0.05). The positive 
      expression of p53 in LSCC was significantly higher than that in para-cancerous 
      tissues and polyp specimens from vocal cord tissues (P < 0.05). The positive 
      expressions of p53 were related to the differentiation grades, cervical lymph 
      node metastasis and prognosis (P < 0.05). There was no significance correlation 
      between BAG-1 and p53 expression (P > 0.05). CONCLUSION: Over expression of BAG-1 
      and p53 play an important role in the process of development of LSCC; BAG-1 may 
      be a biological predictor of early period in LSCC, especially nuclear BAG-1 
      localization may be a prediction of unfavorable outcome. Expression of p53 is 
      related with cervical lymph node metastasis, and that is a prognostic target.
FAU - Wu, Shuhui
AU  - Wu S
AD  - Department of Otolaryngology, Zhongnan Hospital of Wuhan University, Wuhan, 
      430071, China. wsh-1227@163.com
FAU - Jiang, Xiaoqing
AU  - Jiang X
FAU - Zhou, Xuhong
AU  - Zhou X
FAU - Yin, Shucheng
AU  - Yin S
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (BCL2-associated athanogene 1 protein)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Carcinoma, Squamous Cell/genetics/*metabolism
MH  - DNA-Binding Proteins/genetics/*metabolism
MH  - Humans
MH  - Laryngeal Neoplasms/genetics/*metabolism
MH  - Lymphatic Metastasis
MH  - Prognosis
MH  - Transcription Factors/genetics/*metabolism
MH  - Tumor Suppressor Protein p53/genetics/*metabolism
EDAT- 2006/01/10 09:00
MHDA- 2011/04/06 06:00
CRDT- 2006/01/10 09:00
PHST- 2006/01/10 09:00 [pubmed]
PHST- 2011/04/06 06:00 [medline]
PHST- 2006/01/10 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Oct;19(20):932-5.