PMID- 1639957
OWN - NLM
STAT- MEDLINE
DCOM- 19920903
LR  - 20181130
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 75
IP  - 2
DP  - 1992 Aug
TI  - Aldosterone-secreting adrenal adenoma as part of multiple endocrine neoplasia 
      type 1 (MEN1): loss of heterozygosity for polymorphic chromosome 11 
      deoxyribonucleic acid markers, including the MEN1 locus.
PG  - 564-70
AB  - A 63-year-old female presented with the extremely rare occurrence of an 
      aldosterone-secreting adrenocortical adenoma as part of the syndrome of multiple 
      endocrine neoplasia type 1 (MEN1). Only two other MEN1 patients were reported in 
      the literature with hyperaldosteronism. The patient's MEN1 syndrome consisted of 
      the association of primary hyperparathyroidism due to parathyroid adenoma, a 
      prolactinoma, and a toxic multinodular goiter. Elevated basal and meal-stimulated 
      serum PP levels without demonstrable pancreatic tumor were also found. Genetic 
      analysis of the aldosterone-secreting adenoma with DNA markers localized on 
      chromosome 11 showed loss of heterozygosity in tumor DNA. Since the MEN1 syndrome 
      is caused by loss of the tumor suppressor gene on chromosome 11 in the 11q13 
      region, it is probable that the same mechanism is associated with the formation 
      of the adrenocortical adenoma.
FAU - Beckers, A
AU  - Beckers A
AD  - Department of Endocrinology, University of Liege, Belgium.
FAU - Abs, R
AU  - Abs R
FAU - Willems, P J
AU  - Willems PJ
FAU - van der Auwera, B
AU  - van der Auwera B
FAU - Kovacs, K
AU  - Kovacs K
FAU - Reznik, M
AU  - Reznik M
FAU - Stevenaert, A
AU  - Stevenaert A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Genetic Markers)
RN  - 4964P6T9RB (Aldosterone)
SB  - IM
MH  - Adenoma/genetics/*metabolism
MH  - Adrenal Gland Neoplasms/genetics/*metabolism
MH  - Aldosterone/*metabolism
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 11
MH  - *Endocrine Gland Neoplasms/complications/metabolism
MH  - Endocrine Glands/metabolism
MH  - Female
MH  - *Genetic Markers
MH  - *Heterozygote
MH  - Humans
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Syndrome
EDAT- 1992/08/01 00:00
MHDA- 1992/08/01 00:01
CRDT- 1992/08/01 00:00
PHST- 1992/08/01 00:00 [pubmed]
PHST- 1992/08/01 00:01 [medline]
PHST- 1992/08/01 00:00 [entrez]
AID - 10.1210/jcem.75.2.1639957 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1992 Aug;75(2):564-70. doi: 10.1210/jcem.75.2.1639957.