PMID- 16400035
OWN - NLM
STAT- MEDLINE
DCOM- 20060323
LR  - 20181113
IS  - 0002-9440 (Print)
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 168
IP  - 1
DP  - 2006 Jan
TI  - Hepatocyte growth factor/scatter factor and MET are involved in arterial repair 
      and atherogenesis.
PG  - 340-8
AB  - Several studies have shown that in the arterial wall hepatocyte growth 
      factor/scatter factor (HGF/SF) is expressed by smooth muscle cells (SMCs) but 
      acts on endothelial cells, not SMCs. Other studies, however, have indicated that 
      SMCs can respond to HGF/SF. We have reinvestigated expression and activity of 
      HGF/SF and its receptor MET in arterial SMC and endothelial cell cultures and in 
      whole arteries after superficial or deep injury or atherogenesis. High-density 
      cultures of SMCs produced HGF/SF but did not express MET, whereas SMCs, at the 
      leading edge of injured cultures, expressed both ligand and receptor and showed a 
      dramatic motility and growth response to HGF/SF. In line with these results, 
      HGF/SF and MET expression was undetectable in the media of uninjured carotid 
      arteries but was induced after deep arterial injury in areas of SMC migration in 
      the neointima. Strong MET expression was also observed in the SMCs of the 
      atherosclerotic lesions of homozygous apoE(-/-) mice, whereas HGF/SF was 
      expressed by macrophage-derived foam cells. These results demonstrate that MET is 
      induced in migrating and proliferating SMCs and that HGF/SF and MET are key 
      mediators of the SMC response in atherogenesis.
FAU - McKinnon, Heather
AU  - McKinnon H
AD  - Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
FAU - Gherardi, Ermanno
AU  - Gherardi E
FAU - Reidy, Michael
AU  - Reidy M
FAU - Bowyer, David
AU  - Bowyer D
LA  - eng
GR  - R01 HL070858/HL/NHLBI NIH HHS/United States
GR  - HL070858/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Animals
MH  - Arteries/*injuries
MH  - Atherosclerosis/*physiopathology
MH  - Blotting, Western
MH  - Cell Movement/physiology
MH  - Cells, Cultured
MH  - Endothelium, Vascular/metabolism
MH  - Hepatocyte Growth Factor/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Mice
MH  - Muscle, Smooth, Vascular/metabolism
MH  - Myocytes, Smooth Muscle/*metabolism
MH  - Organ Culture Techniques
MH  - Proto-Oncogene Proteins c-met/*metabolism
PMC - PMC1592681
EDAT- 2006/01/10 09:00
MHDA- 2006/03/24 09:00
PMCR- 2006/07/01
CRDT- 2006/01/10 09:00
PHST- 2006/01/10 09:00 [pubmed]
PHST- 2006/03/24 09:00 [medline]
PHST- 2006/01/10 09:00 [entrez]
PHST- 2006/07/01 00:00 [pmc-release]
AID - S0002-9440(10)62095-0 [pii]
AID - 10.2353/ajpath.2006.050379 [doi]
PST - ppublish
SO  - Am J Pathol. 2006 Jan;168(1):340-8. doi: 10.2353/ajpath.2006.050379.