PMID- 16400526
OWN - NLM
STAT- MEDLINE
DCOM- 20070427
LR  - 20181113
IS  - 1567-2379 (Print)
IS  - 1567-2379 (Linking)
VI  - 36
IP  - 6-7
DP  - 2005 Sep
TI  - Localization of epidermal-type fatty acid binding protein in macrophages in 
      advanced atretic follicles of adult mice.
PG  - 391-400
AB  - The localization of epidermal-type fatty acid binding protein (E-FABP) in the 
      mature mouse ovary was examined by immuno-light and electron microscopy. Numerous 
      macrophages immunopositive for both anti-E-FABP and F4/80 antibodies, together 
      with immunonegative cells, were found in advanced atretic follicles that had 
      eccentric lumens containing deformed ova. While some E-FABP-immunopositive 
      macrophages were spider in shape and appeared singly, others, especially close to 
      the lumen, were round and voluminous and tended to be aggregated. The voluminous 
      macrophages contained phagosomes of various sizes and they were regarded as those 
      actively involved in the phagocytosis of apoptotic granulosa cells. 
      E-FABP-immunopositive macrophages and their processes were often apposed to 
      adjacent immunonegative cells, and some of them lined the lumen containing 
      deformed ova. On the other hand, E-FABP-immunonegative cells in the atretic 
      follicles were classified into two types: the one, a minority, was characterized 
      by small mitochondria containing non-tubular cristae and presumably represented 
      residual granulosa cells, while the other dominant type was characterized by 
      large mitochondria containing tubular cristae and presumably represented theca 
      cells originally surrounding the follicles to be atretic. The present detection 
      of E-FABP-immunopositivity selectively in macrophages of the atretic follicles 
      suggests possible involvement of E-FABP and/or its ligand fatty acids in the 
      process of follicular atresia, and it makes more reliable the identification of 
      the advanced atretic follicles with the antral spaces obliterated, which could 
      provide further details on the histology of the follicular atresia than before.
FAU - Nourani, Mohammad Reza
AU  - Nourani MR
AD  - Division of Histology, Department of Cell Biology, Graduate School of Medicine, 
      Tohoku University, Aoba-ku, Sendai, Japan.
FAU - Owada, Yuji
AU  - Owada Y
FAU - Kitanaka, Noriko
AU  - Kitanaka N
FAU - Abdelwahab, Soha Abdelkawi
AU  - Abdelwahab SA
FAU - Iwasa, Hiroo
AU  - Iwasa H
FAU - Sakagami, Hiroyuki
AU  - Sakagami H
FAU - Spener, Friedrich
AU  - Spener F
FAU - Kondo, Hisatake
AU  - Kondo H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060107
PL  - Netherlands
TA  - J Mol Histol
JT  - Journal of molecular histology
JID - 101193653
RN  - 0 (Fabp3 protein, mouse)
RN  - 0 (Fabp5 protein, mouse)
RN  - 0 (Fatty Acid Binding Protein 3)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Animals
MH  - Fatty Acid Binding Protein 3
MH  - Fatty Acid-Binding Proteins/*metabolism
MH  - Female
MH  - Macrophages/cytology/*metabolism/ultrastructure
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neoplasm Proteins/*metabolism
MH  - Ovarian Follicle/*cytology/*metabolism/ultrastructure
MH  - Protein Transport
EDAT- 2006/01/10 09:00
MHDA- 2007/04/28 09:00
CRDT- 2006/01/10 09:00
PHST- 2005/05/23 00:00 [received]
PHST- 2005/07/27 00:00 [accepted]
PHST- 2006/01/10 09:00 [pubmed]
PHST- 2007/04/28 09:00 [medline]
PHST- 2006/01/10 09:00 [entrez]
AID - 10.1007/s10735-005-9005-6 [doi]
PST - ppublish
SO  - J Mol Histol. 2005 Sep;36(6-7):391-400. doi: 10.1007/s10735-005-9005-6. Epub 2006 
      Jan 7.