PMID- 16400948
OWN - NLM
STAT- MEDLINE
DCOM- 20070329
LR  - 20080206
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 30
IP  - 21
DP  - 2005 Nov
TI  - [Effect of Huchang Qingfei concentrated pellets on E-cadherin expression in lung 
      tissue of mice infected with Mycoplasma pneumoniae].
PG  - 1682-5
AB  - OBJECTIVE: To investigate the effects of Huchang Qingfei concentrated pellets on 
      the expression of E-cadherin (E-cd) in the lung tissue from mice infected with 
      Mycoplasma pneumoniae (MP). METHOD: A mice model of Mycoplasmal pneumonia (MPP) 
      was developed by repeatedly intranasal infectious route. Transmission electronic 
      microscope (TEM) and immunohistochemistry stain were performed to observe the 
      pathological changes and expression of E-cd in lung tissues. RESULT: Under TEM it 
      was found that the cellular membrane was ruptured, mitochondria was denatured, 
      crista was broken in the pulmonary cells of the model group; the all above 
      parameters in Huchang medicated group were improved obviously. The 
      immunohistochemistry test showed that strong positive brown stain of E-cd 
      expression was found in the pulmonary epithelial cell membrane and bronchial 
      periphery in the model group, however, in the medicated group, the E-cd 
      expression level in the cellular membrane was decreased and the expression ratio 
      was dropped significantly as compared with the model controls. CONCLUSION: 
      Huchang Qingfei concentrated pellets can inhibit the overexpression of E-cd in 
      the lung tissue of mice with MP-infection, which may be helpful for prevention 
      and treatment of pulmonary injury caused by MPP.
FAU - Wang, Wei-ming
AU  - Wang WM
AD  - Hei Longjiang Academy of Traditional Chinese Medicine Research Institute, Harbin 
      150036, China.
FAU - Li, Ji-chang
AU  - Li JC
FAU - Zhang, Hong-juan
AU  - Zhang HJ
FAU - Yang, Yang
AU  - Yang Y
FAU - Yang, Gui-ying
AU  - Yang GY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Cadherins)
RN  - 0 (Drug Combinations)
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Animals
MH  - Cadherins/*metabolism
MH  - Cell Membrane/metabolism
MH  - Drug Combinations
MH  - Drugs, Chinese Herbal/isolation & purification/*pharmacology
MH  - Epithelial Cells/metabolism
MH  - Female
MH  - Lung/*metabolism/pathology
MH  - Male
MH  - Mice
MH  - Mycoplasma pneumoniae/isolation & purification
MH  - *Plants, Medicinal/chemistry
MH  - Pneumonia, Mycoplasma/*metabolism/microbiology/pathology
MH  - Random Allocation
EDAT- 2006/01/13 09:00
MHDA- 2007/03/30 09:00
CRDT- 2006/01/13 09:00
PHST- 2006/01/13 09:00 [pubmed]
PHST- 2007/03/30 09:00 [medline]
PHST- 2006/01/13 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2005 Nov;30(21):1682-5.