PMID- 1640167
OWN - NLM
STAT- MEDLINE
DCOM- 19920831
LR  - 20190516
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 52
IP  - 1
DP  - 1992 Jul
TI  - Regulatory role of cytokines in IgE-mediated allergy.
PG  - 115-8
AB  - The discovery of immunoglobulin E (IgE) is considered the most important 
      contribution, to date, in the field of clinical allergy. Studies in rodents and 
      humans have suggested that IgE production could be regulated by antigen-specific 
      helper and suppressor T cells and by isotype-specific factors having affinity for 
      IgE. In recent years, the synthesis of IgE has been shown to be regulated, in 
      part, by a cytokine network. This review summarizes the cytokines that 
      up-regulate (interleukins-4, 5, and 6) and down-regulate (interferon-gamma and 
      interleukin-2) the production of IgE. Emphasis is placed on IL-4 and IFN-gamma, 
      two lymphokines known to play a major, but reciprocal, role in IgE synthesis. 
      Increased insight into the various mechanisms of IgE control by cytokines and 
      their receptors will eventually lead to improved treatment strategies in the 
      clinical management of IgE-mediated allergy.
FAU - Tan, H P
AU  - Tan HP
AD  - Immunology Center, Loma Linda University, School of Medicine, California 92354.
FAU - Lebeck, L K
AU  - Lebeck LK
FAU - Nehlsen-Cannarella, S L
AU  - Nehlsen-Cannarella SL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (Cytokines)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Cytokines/*physiology
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Immunoglobulin E/*immunology
RF  - 42
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
AID - 10.1002/jlb.52.1.115 [doi]
PST - ppublish
SO  - J Leukoc Biol. 1992 Jul;52(1):115-8. doi: 10.1002/jlb.52.1.115.