PMID- 16401992
OWN - NLM
STAT- MEDLINE
DCOM- 20060505
LR  - 20071115
IS  - 1341-1098 (Print)
IS  - 1341-1098 (Linking)
VI  - 11
IP  - 6
DP  - 2005 Dec
TI  - Clinical evaluation of combination therapy for biventricular pacing after cardiac 
      surgery in patients with intractable heart failure.
PG  - 408-12
AB  - We examined the effectiveness of combination therapy for biventricular pacing 
      after cardiac surgery. We performed biventricular pacing in seven patients until 
      April 2003. The diagnosis of the patients was ischemic cardiomyopathy (ICM) in 
      four patients and dilated cardiomyopathy (DCM) in three patients. The 
      implantation method of biventricular pacing was performed with a myocardial 
      electrode through a median sternotomy. DDD-R and SSI-R were used to perform 
      biventricular pacing. A Y-adapter was connected to a generator so that the 2 
      leads could be implanted in both the right ventricles (RV) and left ventricles 
      (LV). The clinical symptoms were New York Heart Association (NYHA) classification 
      of 3.7+/-0.3 preoperatively and 1.8+/-0.6 postoperatively, showing a significant 
      improvement (p<0.001). The cardiac index (CI) was 1.9+/-0.2 L/min/m2 
      preoperatively and 3.0+/-0.6 L/min/m2 postoperatively (p<0.05). The pulmonary 
      capillary wedge pressure (PCWP) was 19.5+/-2.6 mmHg preoperatively and 13.6+/-2.0 
      mmHg postoperatively, showing a significant improvement (p<0.05). The 
      intracardiac potential and threshold values were: left atrium 1.9+/-1.0 mV, 
      threshold value (PW: 0.45 msec) 2.1+/-0.6 V, LV 4.9+/-4.23 mV, threshold value 
      (PW: 0.45 msec) 2.2+/-1.51 V, and RV 3.6+/-0.9 V, threshold value (PW: 0.45 msec) 
      2.0+/-0.7 V. The LV and RV threshold values were high. The QRS interval improved 
      from 158.4+/-18.0 msec preoperatively to 110+/-13.4 msec postoperatively, showing 
      a significant reduction. This combination therapy when compared to the use of the 
      biventricular pacing method used at the current time, does have the risks of 
      cardiac surgery, but the clinical symptoms and hemodynamic performance 
      improvement are great.
FAU - Sakamoto, Shigeru
AU  - Sakamoto S
AD  - Department of Cardiovascular Surgery, Kanazawa Medical University, Ishikawa, 
      Japan.
FAU - Matsubara, Junichi
AU  - Matsubara J
FAU - Nagayoshi, Yasuhiro
AU  - Nagayoshi Y
FAU - Nishizawa, Hisateru
AU  - Nishizawa H
FAU - Takeuchi, Katsunori
AU  - Takeuchi K
FAU - Nonaka, Toshimichi
AU  - Nonaka T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Ann Thorac Cardiovasc Surg
JT  - Annals of thoracic and cardiovascular surgery : official journal of the 
      Association of Thoracic and Cardiovascular Surgeons of Asia
JID - 9703158
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiac Pacing, Artificial/*methods
MH  - Cardiomyopathies/surgery/*therapy
MH  - Cardiomyopathy, Dilated/surgery/*therapy
MH  - Electrocardiography
MH  - Electrodes, Implanted
MH  - Female
MH  - Heart Failure/surgery/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/surgery/*therapy
EDAT- 2006/01/13 09:00
MHDA- 2006/05/06 09:00
CRDT- 2006/01/13 09:00
PHST- 2006/01/13 09:00 [pubmed]
PHST- 2006/05/06 09:00 [medline]
PHST- 2006/01/13 09:00 [entrez]
PST - ppublish
SO  - Ann Thorac Cardiovasc Surg. 2005 Dec;11(6):408-12.