PMID- 16403420
OWN - NLM
STAT- MEDLINE
DCOM- 20061013
LR  - 20061115
IS  - 0045-6535 (Print)
IS  - 0045-6535 (Linking)
VI  - 64
IP  - 9
DP  - 2006 Aug
TI  - Perfluorinated chemicals in relation to other persistent organic pollutants in 
      human blood.
PG  - 1582-91
AB  - In order to evaluate blood levels of some perfluorinated chemicals (PFCs) and 
      compare them to current levels of classical persistent organic pollutants (POPs) 
      whole blood samples from Sweden were analyzed with respect to 12 PFCs, 37 
      polychlorinated biphenyls (PCBs), p,p'-dichlorodiphenyl-dichloroethylene (DDE), 
      hexachlorobenzene (HCB), six chlordanes and three polybrominated diphenyl ethers 
      (PBDEs). The median concentration, on whole blood basis, of the sum of PFCs was 
      20-50 times higher compared to the sum of PCBs and p,p'-DDE, 300-450 times higher 
      than HCB, sum of chlordanes and sum of PBDEs. Estimations of the total body 
      amount of PFCs and lipophilic POPs point at similar body burdens. While levels of 
      for example PCBs and PBDEs are normalized to the lipid content of blood, there is 
      no such general procedure for PFCs in blood. The distributions of a number of 
      perfluorinated compounds between whole blood and plasma were therefore studied. 
      Plasma concentrations were higher than whole blood concentrations for four 
      perfluoroalkylated acids with plasma/whole blood ratios between 1.1 and 1.4, 
      whereas the ratio for perflurooctanesulfonamide (PFOSA) was considerably lower 
      (0.2). This suggests that the comparison of levels of PFCs determined in plasma 
      with levels determined in whole blood should be made with caution. We also 
      conclude that Swedish residents are exposed to a large number of PFCs to the same 
      extent as in USA, Japan, Colombia and the few other countries from which data is 
      available today.
FAU - Karrman, Anna
AU  - Karrman A
AD  - Man-Technology-Environment Research Centre, Department of Natural Sciences, 
      Orebro University, SE-701 82 Orebro, Sweden. anna.karrman@nat.oru.se
FAU - van Bavel, Bert
AU  - van Bavel B
FAU - Jarnberg, Ulf
AU  - Jarnberg U
FAU - Hardell, Lennart
AU  - Hardell L
FAU - Lindstrom, Gunilla
AU  - Lindstrom G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060103
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Adult
MH  - Chromatography, Liquid
MH  - *Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Fluorocarbons/*blood
MH  - Humans
MH  - Male
MH  - Mass Spectrometry
MH  - Middle Aged
MH  - Sweden
EDAT- 2006/01/13 09:00
MHDA- 2006/10/14 09:00
CRDT- 2006/01/13 09:00
PHST- 2005/06/23 00:00 [received]
PHST- 2005/11/09 00:00 [revised]
PHST- 2005/11/10 00:00 [accepted]
PHST- 2006/01/13 09:00 [pubmed]
PHST- 2006/10/14 09:00 [medline]
PHST- 2006/01/13 09:00 [entrez]
AID - S0045-6535(05)01376-7 [pii]
AID - 10.1016/j.chemosphere.2005.11.040 [doi]
PST - ppublish
SO  - Chemosphere. 2006 Aug;64(9):1582-91. doi: 10.1016/j.chemosphere.2005.11.040. Epub 
      2006 Jan 3.