PMID- 16406414
OWN - NLM
STAT- MEDLINE
DCOM- 20061222
LR  - 20060329
IS  - 0378-8741 (Print)
IS  - 0378-8741 (Linking)
VI  - 105
IP  - 1-2
DP  - 2006 Apr 21
TI  - Anti-HIV-1 protease- and HIV-1 integrase activities of Thai medicinal plants 
      known as Hua-Khao-Yen.
PG  - 312-5
AB  - Ethanolic- and water extracts from five species of Thai medicinal plants known as 
      Hua-Khao-Yen were tested for their inhibitory effects against HIV-1 protease 
      (HIV-PR) and HIV-1 integrase (HIV-1 IN). The result revealed that the ethanolic 
      (EtOH) extract of Smilax corbularia exhibited anti-HIV-1 IN activity with an IC50 
      value of 1.9 microg/ml, followed by the water extract of Dioscorea birmanica 
      (IC50 = 4.5 microg/ml), the EtOH extract of Dioscorea birmanica (IC50 = 4.7 
      microg/ml), the water extract of Smilax corbularia (IC50 = 5.4 microg/ml), the 
      EtOH extract of Smilax glabra (IC50 = 6.7 microg/ml) and the water extract of 
      Smilax glabra (IC50 = 8.5 microg/ml). The extracts of Pygmaeopremna herbacea and 
      Dioscorea membranacea were apparently inactive (IC50 > 100 microg/ml). 
      Interestingly, only the EtOH extract of Dioscorea membranacea showed appreciable 
      activity (IC50 = 48 microg/ml) against HIV-1 PR, while the other extracts 
      possessed mild activity. This result strongly supported the basis for the use of 
      Smilax corbularia and Dioscorea membranacea for AIDS treatment by Thai 
      traditional doctors.
FAU - Tewtrakul, Supinya
AU  - Tewtrakul S
AD  - Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical 
      Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand. 
      supinya.t@psu.ac.th
FAU - Itharat, Arunporn
AU  - Itharat A
FAU - Rattanasuwan, Pranee
AU  - Rattanasuwan P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060106
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (DNA Primers)
RN  - 0 (HIV Integrase Inhibitors)
RN  - 0 (HIV Protease Inhibitors)
RN  - 0 (Plant Extracts)
RN  - EC 2.7.7.- (HIV Integrase)
RN  - EC 3.4.23.- (HIV Protease)
SB  - IM
MH  - Base Sequence
MH  - DNA Primers
MH  - HIV Integrase/*drug effects
MH  - HIV Integrase Inhibitors/*pharmacology
MH  - HIV Protease/*drug effects
MH  - HIV Protease Inhibitors/*pharmacology
MH  - Plant Extracts/*pharmacology
MH  - *Plants, Medicinal/chemistry/classification
MH  - Species Specificity
EDAT- 2006/01/13 09:00
MHDA- 2006/12/23 09:00
CRDT- 2006/01/13 09:00
PHST- 2005/08/12 00:00 [received]
PHST- 2005/10/19 00:00 [revised]
PHST- 2005/11/14 00:00 [accepted]
PHST- 2006/01/13 09:00 [pubmed]
PHST- 2006/12/23 09:00 [medline]
PHST- 2006/01/13 09:00 [entrez]
AID - S0378-8741(05)00770-1 [pii]
AID - 10.1016/j.jep.2005.11.021 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2006 Apr 21;105(1-2):312-5. doi: 10.1016/j.jep.2005.11.021. 
      Epub 2006 Jan 6.